来自海洋来源的生物活性:对免疫调节,微生物群调节和肠道屏障保护的机械洞察
Farman Ali1, Dailin Li1, Yunpeng Su1
1College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
International journal of molecular sciences
|November 13, 2025
概括
来自章鱼,贝类和贝的海洋对肠道健康有很大的前景. 这些天然化合物调节免疫系统,减少炎症,改善肠道微生物群平衡,帮助诸如炎症性肠病等疾病.
科学领域:
- 海洋生物技术 海洋生物技术
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 海洋生物活性化合物,特别是,因其健康益处而受到越来越多的关注.
- 这些具有免疫调节,抗氧化和肠道微生物群调节的特性.
- 它们为炎症性肠病 (IBD) 和相关的胃肠道疾病提供了潜在的治疗策略.
研究的目的:
- 对来自章鱼,海贝和的海洋衍生的当前研究进行审查.
- 突出它们在恢复肠道完整性和免疫功能方面的治疗潜力.
- 探索它们的作用机制和在肠道健康及其他领域的应用.
主要方法:
- 审查关于海洋的现有文献.
- 在体内研究的分析,包括硫酸 (DSS) 诱导的大肠炎和环胺诱导的免疫抑制模型.
- 检查涉及紧密结合蛋白质,炎症途径和肠道微生物群组成的分子机制.
主要成果:
- 海洋有效地通过增加密集结蛋白 (ZO-1,ocludin) 和粘素生产来恢复肠道完整性.
- 它们通过减少促炎性细胞因子和抑制NF-κB和TLR-4等途径来调节免疫反应.
- 这些可以促进有益的肠道细菌,如Lactobacillus和Lachnospiraceae,重新平衡不良的微生物群.
结论:
- 来自特定贝类的海洋衍生体显示出对胃肠道健康的显著治疗潜力.
- 它们与肠道-免疫-微生物群轴相互作用的能力使它们在治疗IBD和免疫功能障碍方面具有价值.
- 对于这些多功能海洋生物活性物质,需要对临床转化和药物开发进行进一步的研究.
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