纳米过渡金属复合物的重要性作为抗癌和抗菌治疗剂
Abdulaziz Alshehab1,2, Ameena Haider3, Laila Jaragh-Alhadad2
1College of Graduate Studies, Kuwait University, Kuwait City 13060, Kuwait.
International journal of molecular sciences
|November 13, 2025
概括
合成和测试了铜,和复合物. 铜复合体显示出作为抗癌和抗菌剂的显著潜力,表现优于和的对应物.
科学领域:
- 无机化学 无机化学
- 药用化学 医学化学
- 计算化学计算化学
背景情况:
- 金属复合物有着悠久的药用历史,作为诊断和输送剂提供了好处.
- 它们表现出各种治疗性质,包括抗感染,抗微生物,抗糖尿病和神经活动.
- 希夫基联体是开发新型金属基治疗剂的多功能支架.
研究的目的:
- 使用希夫基联体合成和表征 (Co), (Zn) 和铜 (Cu) 复合物.
- 评估这些金属复合物的体外抗癌活性与MDA-MB-453乳腺癌细胞系相比.
- 评估合成复合物的抗菌功效,以对抗阳性和阴性细菌.
主要方法:
- 通过希夫基反应合成Co,Zn和Cu复合物.
- 合成的金属复合物的完整表征.
- 在体外细胞毒性测定使用MDA-MB-453乳腺癌细胞系.
- 对代表性格拉姆阳性和格拉姆阴性细菌菌株进行抗菌活性测试.
- 密度函数理论 (DFT) 计算以支持实验发现.
主要成果:
- 铜配体复合体对MDA-MB-453乳腺癌细胞系表现出最高的强度.
- 合成的和复合物也表现出抗癌活性,尽管比铜的活性要小.
- 铜复合体对阳性和阴性细菌表现出显著的抑制作用.
- DFT计算证实了关于复合体活动的实验观测.
结论:
- 铜联体复合物是抗癌和抗菌疗法的非常有前途的候选者.
- 金属复合物,特别是基于铜的复合物,需要进一步研究药物应用.
- 这项研究突出了希夫基础金属复合物的潜力,用于对抗癌症和细菌感染.
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