由肠道微生物群产生的关键信号与代谢综合征,癌症,心血管疾病和大脑功能有关
1Department of Microbiology, Stellenbosch University, Stellenbosch 7600, South Africa.
International journal of molecular sciences
|November 13, 2025
概括
肠道微生物群通过短链脂肪酸 (SCFA) 等信号分子影响大脑功能和疾病. 需要进一步的研究来了解它在认知行为和神经精神疾病中的作用.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群产生信号分子,通过神经 (VN) 影响中枢神经系统 (CNS).
- 短链脂肪酸 (SCFA) 与各种受体相互作用,影响炎症,肠道运动和大脑功能.
- 特定的受体和,如嗅觉受体OR51E1,GLP-1和PrRP在生理和神经过程中发挥作用.
研究的目的:
- 审查肠道微生物群对心血管疾病 (CVD),代谢综合征 (MetS),癌症和大脑功能的影响.
- 突出肠道微生物群衍生分子影响宿主生理和疾病的机制.
- 识别有关肠道微生物组在认知行为和神经精神疾病中的作用的知识差距.
主要方法:
- 临床前和动物研究的文献综述.
- 分析来自科学存储库的信息,包括PubMed,NIH,ScienceDirect,MDPI,Frontiers,Cell Press和CAS内容收集.
- 专注于涉及SCFA,G蛋白结合受体 (GPCR) 和炎症调解体的信号通路.
主要成果:
- SCFA调节炎症反应,肠道运动和神经化学信号传递.
- 丁酸盐与NF-κB和PPARγ的相互作用影响细胞因子的产生,并阻止氧化低密度脂蛋白 (ox-LDL) 的吸收,影响心血管健康.
- 肠道微生物群信号通路与代谢综合征,癌症和大脑功能有关,尽管对认知和神经精神方面的深入研究有限.
结论:
- 肠道微生物群显著影响宿主健康,包括大脑功能和心血管疾病风险.
- 了解这些微生物与宿主相互作用对于开发新型代谢和神经系统疾病治疗策略至关重要.
- 需要进一步的研究来阐明肠道微生物群对认知行为和神经精神疾病的影响的复杂机制.
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