在人类脏疾病中循环和尿路CCL20
Noelia Molina-Cazallas1, Diego García-Ayuso1, Beatriz Fernández-Fernández2,3
1Laboratorio de Nefrología e Hipertensión, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Universidad Autónoma de Madrid (UAM), 28040 Madrid, Spain.
International journal of molecular sciences
|November 13, 2025
概括
在生物流体中,CC动机化学因子联结体20 (CCL20) 的含量升高,在慢性病 (CKD) 中局部产生. 糖尿病病和自身主导性多囊性病中较高的CCL20水平可能有助于风险分层.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- CC动机化学因子配体20 (CCL20) 和它的受体CCR6都与脏炎症有关.
- 糖尿病病 (DKD) 和自身主导性多囊病 (ADPKD) 中CCL20的临床数据有限.
研究的目的:
- 分析DKD和ADPKD患者的血和尿液中的CCL20水平.
- 研究CCL20与基线特征和长期临床结果的关联.
- 为了确定脏中CCL20的来源.
主要方法:
- 对98名DKD和85名ADPKD患者的血和尿液中CCL20水平的分析.
- 利用单细胞转录组学来识别CCL20表达细胞.
- 长期随访 (DKD的中位数为4.9年,ADPKD的7.1年) 以评估临床结果.
主要成果:
- 与参考组相比,DKD和ADPKD患者的血CCL20显著更高.
- 在DKD患者中可以检测出尿液中的CCL20,但在基准组中没有.
- 在DKD中,较高的CCL20与CKD早期阶段和较高的白色素尿相关.
- 在ADPKD中,CCL20升高与较低的eGFR,增加的白蛋白尿和较大的脏大小有关,但与疾病进展或死亡率无关.
结论:
- 在生物流体中,CCL20被上调,并在CKD患者的脏内局部产生.
- CCL20可以作为病风险分层的潜在生物标志物.
- 需要进一步的研究,以充分阐明CCL20在CKD中的作用和临床效用.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
537
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
537
Renal Corpuscle
6.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.9K
Renal Tubule and Collecting Duct
3.0K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
3.0K
Chronic Kidney Disease I: Introduction
552
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
552
Acute Kidney Injury II: Pathophysiology
865
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
865
Renal Drug Excretion: Tubular Secretion
753
Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
753


