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Updated: Jan 11, 2026

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在c-MYC推广区域内探索关尼基团参与与G-四重复基因的霍达丁相互作用的参与

Denise Dozio1, Aziza Caccia1, Sabrina Dallavalle1

  • 1Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, Via Celoria 2, 20133 Milan, Italy.

International journal of molecular sciences
|November 13, 2025
PubMed
概括

含guanidinium的化合物有效地结合和稳定G-四复合体 (G4s),这是关键的DNA结构. 福衍生物显示显著的相互作用,影响G4稳定性,并对癌细胞表现出细胞毒性作用.

关键词:
在G-quadruplex中使用.核磁共振光谱法 (NMR) 是一种光谱法.细胞毒性活动的细胞毒性.停靠的对接方式瓜尼尼丁是一种.霍尔达丁 (hordatine) 是一种类型的药物.

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