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细胞对铜纳米颗粒的代谢反应:正常和乳腺癌细胞之间的比较

Alexandra Ivan^1,2, Maria-Alexandra Pricop^2,3, Alexandra Teodora Lukinich-Gruia²

¹Department of Functional Sciences, Center of Immuno-Physiology (CIFBIOTEH), University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Sq. 2, 300041 Timisoara, Romania.

International journal of molecular sciences

|November 13, 2025

概括

铜纳米颗粒 (CuNPs) 显示出作为一种低成本的癌症治疗的希望. 较高的CuNP剂量有效地减少了乳腺癌细胞 (SKBR3),同时节省了健康的干细胞 (MSC),表明了个性化治疗的潜力.

科学领域:

纳米医学是一种纳米医学.
生物技术是生物技术.
在瘤学瘤学.

背景情况:

铜纳米粒子 (CuNPs) 为癌症治疗提供了一种具有成本效益的方法.
研究CuNP对癌细胞和健康干细胞的影响对于治疗开发至关重要.

研究的目的:

评估不同度的CuNP对SKBR3乳腺癌细胞和介酶干细胞 (MSC) 的细胞毒性和代谢作用.
探索CuNPs作为向癌症治疗剂的潜力.

主要方法:

使用基于阻抗的测定来评估CuNP细胞毒性.
细胞反应通过亡测定,反应性氧物种 (ROS) 测量,基因表达分析 (CAT,SOD),线粒体呼吸评估和脂肪酸甲基 (FAME) 分析进行评估.

主要成果:

较高的CuNP度表明SKBR3细胞指数的剂量依赖性下降和诱导的亡.
与MSC相比,SKBR3细胞表现出增加的CAT和SOD基因表达和更高的基线呼吸能力.
多重体细胞表现出脂肪酸甲基 (FAMEs) 的丰度高于SKBR3细胞.

结论:

对于乳腺癌细胞 (SKBR3),CuNPs表现出对乳腺癌细胞 (SKBR3) 的选择性毒性,而不是对介质细胞干细胞 (MSC) 的选择性毒性.
不同的代谢概况和对CuNPs的反应表明了个性化乳腺癌治疗策略的潜力.

关键词:

在体外毒性 in vitro毒性代谢生物组的代谢生物组纳米材料的使用方法氧化应激是一种氧化应激.

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