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孕期糖尿病暴露的介酶干细胞:表型差异与后代的长期健康有关

Mark J Pandrich¹, Nishel M Shah¹, Isabel Garcia Perez¹

¹Imperial College London, London SW7 2AZ, UK.

International journal of molecular sciences

|November 13, 2025

概括

妊娠期糖尿病 (GDM) 的怀孕中产卵性干细胞 (MSC) 可能表现出改变的表型,反映出胎儿编程. 这些GDM-MSC可以作为后代健康风险的生物标志物,如肥胖和2型糖尿病 (T2DM).

科学领域:

生殖生物学生殖生物学
内分泌学在内分泌学.
干细胞研究的研究.

背景情况:

母亲的孕期糖尿病 (GDM) 与后代的不良长期健康结果有关,包括肥胖和2型糖尿病 (T2DM).
介质干细胞 (MSC) 在胎儿发育中至关重要,它们的特性可能受孕期间母亲代谢环境的影响.
在GDM怀孕中,母亲的环境可能会诱导表观遗传变化或改变胎儿衍生的MSCs的表型,从而导致胎儿编程的改变.

研究的目的:

审查目前关于暴露于GDM的MSCs (GDM-MSCs) 现型的研究.
探索GDM-MSC如何阐明胎儿编程的机制.
讨论GDM-MSCs作为后代长期健康的生物标志物以及评估干预措施的工具的潜力.

主要方法:

审查最近的科学文献和研究.
关于GDM-MSC表型的表征.
分析母亲的GDM和MSC属性之间的联系.

主要成果:

与健康怀孕的MSC相比,GDM-MSC表现出明显的表型特征.
这些变化的表型表明MSCs在GDM条件下调解胎儿编程方面发挥了作用.
这些发现增强了对GDM环境如何通过MSCs影响胎儿发育的理解.

结论:

GDM-MSCs的表型为胎儿编程机制提供了洞察力.
GDM-MSCs显示为后代对代谢疾病易感性的预测生物标志物具有前景.
需要进一步的翻译研究来将GDM-MSC表型与临床结果和治疗策略联系起来.

关键词:

疾病的发育起源.怀孕期间糖尿病在怀孕期间糖尿病孕期糖尿病孕期糖尿病介质细胞干细胞介质细胞干细胞介质细胞层细胞.

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