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子宫内膜微生物组和生殖受体性:不同的观点

Galina Stoyancheva¹, Nikolina Mihaylova², Maria Gerginova¹

¹Department of Microbial Genetics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

International journal of molecular sciences

|November 13, 2025

概括

以前被认为是无菌的子宫内膜微生物组,对于生殖健康至关重要. 它的成分影响植入成功,有益的细菌促进平衡和与不孕症相关的失生症.

科学领域:

生殖医学和微生物学
人类微生物组研究研究
基因组学和多基因组学研究

背景情况:

人体子宫内膜是一个动态的微生物,对生殖健康至关重要.
测序技术的进步揭示了子宫内膜微生物组的复杂性.
微生物组的作用超出了构成范围,可以主持影响植入的相互作用.

研究的目的:

审查目前关于子宫微生物组对植入成功的影响的知识.
分析子宫内膜微生物组,免疫学和氧化应激之间的相互作用.
突出微生物组分析对生殖生物标志物和干预措施的潜力.

主要方法:

使用16S rRNA测序和猎枪元基因组学研究的综述.
综合文化学和3D子宫内膜模型的研究分析.
结合了微生物学,免疫学和宿主相互作用研究的发现.

主要成果:

乳杆菌的占主导地位与子宫内膜稳态和积极的生殖结果有关.
微生物失生症,以增加的多样性和特定的厌氧种类标志,与植入失败和慢性子宫内膜炎相关.
子宫内膜微生物群通过免疫,代谢和表观遗传途径与宿主相互作用,影响胚胎植入.

结论:

子宫内膜微生物组是繁殖成功的关键因素.
研究协议的标准化对于解决当前发现的差异至关重要.
子宫内膜微生物组分析具有作为不孕不育的生物标志物和治疗点的潜力.

关键词:

3D人类子宫内膜培养模型牛乳杆菌 (Lactobacillus) 是一种细菌.乳酸菌的抗氧化活性.胚胎内膜的微生物组免疫机制的免疫机制.氧化应激是一种氧化应激.

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