相关实验视频

Updated: Jun 12, 2026

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

与BMAL1和CLOCK基因多态性与孕前风险的关联与亚型分析

Fan Xia¹, Peiwen Wang¹, Ziye Li¹

¹Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, No. 172 Tongzipo Road, Yuelu District, Changsha 410013, China.

International journal of molecular sciences

|November 13, 2025

概括

在BMAL1基因的遗传变异可能会防止孕前 (PE),特别是早期发病的PE. 特定的BMAL1单核酸多态 (SNP) 与降低PE风险和改变BMAL1基因表达有关.

科学领域:

遗传学是一个遗传学.
产科产科产科产科产科
分子生物学分子生物学

背景情况:

孕前 (PE) 是一种严重的高血压妊娠障碍,原因不明.
在PE病变发生过程中,人们怀疑循环基因失调,包括BMAL1和CLOCK.
遗传变异在PE敏感性中的BMAL1和CLOCK的作用尚不清楚.

研究的目的:

研究BMAL1和CLOCK基因中的遗传多态化与孕前风险之间的关联.
探索这些多形态对BMAL1mRNA表达和蛋白质相互作用的影响.

主要方法:

病例控制研究涉及202名PE患者和400名对照人群.
使用MassARRAY进行BMAL1和CLOCK单核酸多态 (SNP) 的基因定型.
链接不平衡修剪选择标签SNP进行关联分析.
表达量的特征位置 (eQTL) 和蛋白质-蛋白质相互作用分析.

主要成果:

在CLOCK基因变异与PE之间没有发现显著的关联.
BMAL1 rs11022780变种显示出对PE的显著保护作用,特别是在早期发病的PE (eoPE) 中.
eQTL分析证实rs11022780影响全血中的BMAL1mRNA水平.

结论:

在BMAL1中的遗传变异,特别是rs11022780 SNP,可能提供了预防先兆子的保护机制.
在昼夜网络中BMAL1的作用表明影响PE发展的基因调节途径.
对BMAL1的功能进行进一步的研究可能会揭示PE的新型治疗点.

关键词:

在 BMAL1 中,钟表的时间昼夜节律昼夜节律孕前症是什么意思怀孕怀孕怀孕怀孕怀孕

更多相关视频

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

相关概念视频

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...