久坐不动行为作为患有代谢功能障碍相关性肝病 (MASLD) 患者肝纤维化发展的危险因素:一项跨部门研究
Antonella Bianco1, Caterina Bonfiglio2, Isabella Franco1
1Laboratory of Movement and Wellness, National Institute of Gastroenterology IRCCS "Saverio de Bellis", Castellana Grotte, 70013 Bari, Italy.
对日常能量消耗的客观测量表明,久坐不动的行为与代谢功能障碍相关的脂肪肝疾病 (MASLD) 的成年人肝硬度增加有关. 减少久坐时间可能有助于减缓纤维化进展.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪肝病 (MASLD) 影响了20%的意大利人,每年为NHS造成794亿欧元的损失.
- 晚期肝纤维化是MASLD患者不良结果的关键预测因素.
- 久坐不动行为 (SB) 是一个可修改的风险因素,但证据通常依赖于自我报告的数据.
研究的目的:
- 为了调查客观测量的每日能量消耗和MASLD成年人的肝硬度之间的联系.
- 为了确定这种人群中静坐行为是否与肝硬度增加有关.
主要方法:
- 对104名肥胖和中度至重度肥胖症的成年人 (18-65岁) 的横截面分析.
- 客观评估每日能源消耗使用7天的手腕穿戴动图 (METs/day).
- 通过暂时弹性学 (FibroScan®) 进行肝硬度 (LSM,kPa) 的非侵入性测量.
主要成果:
- 较低的每日能量消耗独立地与更高的肝硬度相关 (p=0.002).
- 每一个1-MET增加与1.239 kPa的肝硬度降低相关.
- 久坐不动的人 (≤1.5METs) 与非久坐不动的人相比,肝硬度显著增加 (p=0.03).
结论:
- 客观测量的久坐行为独立地与肥胖的MASLD患者的肝硬度增加有关.
- 减少久坐时间可能是缓解肝纤维化进展的实际策略.
- 需要进一步的纵向研究来确认因果关系并评估在更广泛的MASLD人群中的干预措施.
更多相关视频
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
08:41Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
相关概念视频
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
