结核病和慢性阻塞性肺病之间的双向关联:系统性审查和元分析
Jingyuan Feng1, Minghao Hu1, Hongfei Duan1
1Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing 101125, China.
Journal of clinical medicine
|November 13, 2025
概括
结核病 (TB) 和慢性阻塞性肺病 (COPD) 显著增加患另一种疾病的风险. 综合管理策略对于这两种疾病至关重要,特别是在结核病负担较高的地区.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 和慢性阻塞性肺病 (COPD) 是全球领先的呼吸道疾病.
- 结核病和COPD之间潜在的双向联系需要全面调查.
研究的目的:
- 系统地评估结核病和COPD之间的流行病学关联.
- 量化患有另一种疾病的患者患上一种疾病的风险.
主要方法:
- 在2025年8月之前对观察性研究进行系统的文献搜索.
- 使用随机效应模型对合并的几率比率和流行率的元分析.
- 评估异质性和出版偏见.
主要成果:
- 分析了32项涉及超过67万名参与者的研究.
- 结核病史增加了COPD风险 (OR=2.46);COPD增加了结核病风险 (OR=2.21).
- 综合患病率:15.95%的结核病患者患有COPD;5.57%的结核病患者患有COPD.
结论:
- 结核病和COPD之间存在显著的双向关联.
- 每一种疾病都是另一个疾病的独立风险因素.
- 综合查和管理至关重要,特别是在结核病负担较高的地区.
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