长期和大量吸烟作为腰椎脊柱狭窄症的危险因素:来自大规模全国人口基队列的证据
Ji-Hyun Ryu1, Ki-Won Kim1, Ju-Yeong Kim2
1Department of Orthopedic Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Republic of Korea.
Journal of clinical medicine
|November 13, 2025
概括
吸烟会增加腰椎脊柱狭窄症 (LSS) 的风险,尤其是在更重,长期暴露的情况下. 戒烟对于减少脊髓退行至关重要,特别是在老年人和女性中.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 腰椎脊柱狭窄症 (LSS) 是老年人残疾的一个重要原因.
- 吸烟对LSS发展的具体影响需要进一步澄清.
- 了解吸烟的作用对于有针对性的预防策略至关重要.
研究的目的:
- 调查吸烟与腰椎脊柱狭窄症 (LSS) 的发生率之间的关联.
- 检查剂量-反应关系以及跨年龄和性别子组的风险变化.
- 提供证据支持戒烟干预措施对脊柱健康的支持.
主要方法:
- 一项全国性的基于人口的队列研究,利用韩国国家医疗保险服务数据库.
- 包括2009年查的40岁以上的200多万成年人,并追踪到2020年.
- 使用Cox比例危险模型进行分析,并根据多种混因素进行调整.
主要成果:
- 与从未吸烟者相比,在以前和现在的吸烟者中观察到一个统计学上显著的LSS风险增加.
- 显而易见的是剂量与反应的明显关系,与重度吸烟 (≥40包年) 相关的风险最高.
- 在65岁及以上的个体和女性中,吸烟和LSS发病率之间发现了更强烈的关联.
结论:
- 吸烟是发展腰椎脊柱狭窄症 (LSS) 的独立危险因素.
- 随着吸烟的累积终身暴露,LSS的风险比例增加.
- 促进戒烟的公共卫生倡议对于减轻LSS和脊髓退行症的负担至关重要,特别是在弱势群体中.
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