在为原发性甲状腺功能障碍症进行甲状腺切除术后,手术和生化结果的年龄相关差异
Eun Jin Kim1, Jin Kyong Kim1, Sang-Wook Kang1
1Department of Surgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Journal of clinical medicine
|November 13, 2025
概括
原发性甲状腺功能障碍症 (PHPT) 的甲状腺切除术对所有年龄组,包括老年人来说都是安全有效的. 由于其显著的生化和骨效益,年龄不应该阻止手术干预.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 老年医学 老年医学
背景情况:
- 初级甲状腺功能障碍症 (PHPT) 的发生率在老年人中增加.
- 副甲状腺切除术在老年患者中经常被推迟,因为伴随疾病和年龄特异性结局数据有限.
- 这项研究调查了PHPT手术结果与年龄相关的差异.
研究的目的:
- 评估与年龄相关的临床特征差异,手术期间的结果,并发症和PHPT副甲状腺切除术后的生化反应.
- 在不同年龄组中评估副甲状腺切除术的安全性和有效性.
主要方法:
- 对596名经过副甲状腺切除术的患者 (2009-2022) 的回顾性分析.
- 患者分为三个年龄组:<65,65-74岁和≥75岁.
- 人口统计,并发症,手术细节,并发症,病理和生化参数的比较.
主要成果:
- 老年患者患有更多的并发症 (高血压,心血管疾病,糖尿病,骨质疏松症,慢性瘤);年轻患者患有更多的多重内分泌瘤.
- 在不同年龄组中,住院或并发症率 (甲状腺素缺血症,饥饿骨综合征,RLN损伤) 没有显著差异.
- 术后的和副甲状腺激素在所有组中正常化;骨循环标志物在所有年龄段都得到改善,年轻患者的减少更大.
结论:
- 副甲状腺切除术是所有年龄段的PHPT的安全有效治疗方法,包括患有并发症的老年患者.
- 年龄不应该成为PHPT手术干预的障碍,因为PHPT具有明显的生化和骨效益.
- 在老年人中,适当的患者选择是成功手术结果的关键.
相关概念视频
00:59The Parathyroid Glands
4.3K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
4.3K
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
01:40Bone Remodeling
40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K
01:17Hormones and Bone Tissue
3.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.6K
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
180
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
180