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乌帕达西尼布作为性结肠炎患者的第二线或第三线治疗的有效性和安全性:来自现实世界的研究数据
Giammarco Mocci1, Antonio Tursi2,3, Franco Scaldaferri3,4
1Division of Gastroenterology, AORN "Brotzu" Hospital, 09134 Cagliari, Italy.
乌帕达西替尼 (UPA) 是一种有效且安全的治疗性结肠炎 (UC) 患者,在意大利的一项实践研究中表明显著的临床缓解和粘膜愈合. 这种JAK1抑制剂在耐火性UC病例中显示出有前途的结果.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 选择性JAK1抑制剂Upadacitinib (UPA) 现在在意大利为耐火性性结肠炎 (UC) 获得资金.
- 关于UPA在意大利UC患者的有效性和安全性的现实数据有限.
- 过去对耐火性UC的治疗方法包括抗TNF-α,抗整合素和ustekinumab.
研究的目的:
- 评估Upadacitinib (UPA) 在意大利性结肠炎 (UC) 患者的实际有效性和安全性.
- 评估用UPA治疗的UC患者的临床和内镜结局.
- 为耐火UC提供意大利关于UPA的现实数据.
主要方法:
- 对202名连续UC患者的回顾性评估.
- 使用梅奥得分对临床和内镜活动的评估.
- 主要终点集中在UPA的有效性和安全性上.
主要成果:
- 临床缓解率在8周后为45.5%,在随访后为60.2%.
- 临床响应率在8周时为63.5%,在随访时为81.7%.
- 在84.6%的患者中观察到粘膜愈合;在2.5%的患者中观察到不良事件;在2%的患者中观察到大肠切除术.
结论:
- 在大量现实UC患者中,upadacitinib (UPA) 显示出显著的有效性和良好的安全性.
- 这项研究支持UPA作为性结肠炎的有价值的治疗选择.
- 进一步的研究可能会探索UPA在不同治疗线的有效性.
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