对于显著的 mitrale 吐 TEER 后的相对存活率:当代的队列分析
Marcel Almendarez1,2, Isaac Pascual1,2,3, Beatriz Nieves1,2
1Heart Area, Hospital Universitario Central de Asturias, Avenida de Roma S/N, 33011 Oviedo, Spain.
Journal of clinical medicine
|November 13, 2025
概括
过导管边缘到边缘修复 (TEER) 对于 mitrale regurgitation (MR) 显示,女性的生存率有所改善,但男性的过度死亡率持续存在. 整体过度死亡率集中在TEER后的第一年.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 副心脏反 (MR) 是一种普遍的膜心脏病,随着人口老龄化而增加.
- 过导管边缘到边缘修复 (TEER) 是对显著的MR的关键治疗方法.
- TEER对长期生存的影响,特别是基于性别的差异,需要进一步调查.
研究的目的:
- 评估对显著MR的TEER后的相对存活率 (RS) 和过度死亡率 (EM).
- 具体分析TEER后的长期结果中的基于性别的差异.
- 在TEER后确定与MR亚型相关的死亡模式.
主要方法:
- 在2015年10月至2024年8月期间,对253名为显著MR接受TEER的患者进行分析.
- 按性别对患者进行分层,以比较观察到的生存率 (OS) 和过度死亡率 (EM).
- 使用精算生命表和Ederer II方法对匹配的人口数据进行生存估计.
主要成果:
- 总体而言,1年,2年和3年的OS率分别为88.9%,87.4%和78.9%.
- 过度死亡率 (EM) 在TEER后的第一年是最高的 (7.8%),随后下降.
- 与女性相比,男性的相对存活率持续较低,过度死亡率较高,从第一年开始,男性的存活率与同龄人相当.
结论:
- 对于显著MR的TEER后的过度死亡率主要在第一年内观察到.
- 接受TEER的女性的相对存活率与普通人群相提并论,而男性的持续过度死亡率较高.
- 虽然存在基于性别的结果差异,但在调整后,性别不是死亡率的独立预测因素.
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