腰椎脊柱狭窄症与生物加快衰老之间的关联通过PhenoAge估计
Norihiro Isogai1,2,3, Haruki Funao1,3, Ryo Mizukoshi1,3
1Department of Orthopaedic Surgery, School of Medicine, International University of Health and Welfare, Chiba 286-8520, Japan.
腰椎脊柱狭窄症 (LSS) 与较高的生物年龄有关,通过PhenoAge加速 (PhenoAgeAccel) 来衡量. 这种效应在低BMI的老年女性中更为明显,这表明LSS在特定人群中加速衰老.
科学领域:
- 生物遗传学 生物遗传学
- 临床医学 临床医学
- 流行病学 流行病学
背景情况:
- PhenoAge是一种生物标志物,基于生物化学标志物预测死亡风险.
- 费诺Age和腰椎脊柱狭窄症 (LSS) 之间的关系尚不清楚.
- 这项研究调查了LSS患者与对照者的生物年龄差异.
研究的目的:
- 通过使用PhenoAge和PhenoAge加速 (PhenoAgeAccel) 评估腰椎脊柱狭窄症 (LSS) 与生物年龄之间的关联.
- 将手术治疗的LSS患者的PhenoAgeAccel与年龄和BMI匹配的对照进行比较.
- 根据年龄和性别来探索这种关联的变化.
主要方法:
- 包括208名接受手术的LSS患者,按年龄 (≥70) 和性别分类.
- 收集的人口统计数据,血液生物标志物和身体成分.
- 计算了PhenoAgeAccel并将其与LSS患者和匹配的对照组进行了比较.
主要成果:
- 与对照组相比,LSS患者的PhenoAgeAccel显著更高 (-5.7 ± 6.5与 -8.5 ± 3.7年).
- 这种差异在年轻男性,老男性和老女性子组中尤为明显.
- 在LSS老年女性子组中观察到PhenoAgeAccel和BMI之间的弱负相关性.
结论:
- 腰椎脊柱狭窄症在不同年龄和性别群体中对PhenoAgeAccel的影响不同.
- 在LSS的加快衰老效果似乎更显著在老年妇女与较低的BMI.
- PhenoAgeAccel可以作为与LSS相关的健康下降的指标.
更多相关视频
10:39A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
08:46Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
Published on: September 29, 2011
相关概念视频
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Pharmacodynamics in Geriatric Patients: Effects of Age
The Effect of Aging on Tissues
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
