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早期乳腺癌的老年人根据生理年龄的治疗模式:单一机构回顾性研究

Eliza H Lorentzen¹, Yu-Jen Chen², Maria Harvey¹

¹Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.

Journal of clinical medicine

|November 13, 2025

概括

在患有乳腺癌的老年女性中,生理年龄和预期寿命查是常见的. 然而,在这项研究中,这些因素并没有显著影响治疗决策,例如手术或放射治疗.

科学领域:

老年瘤学老年瘤学
乳腺癌治疗方法乳腺癌治疗方法
临床决策临床决策

背景情况:

如果治疗强度与生理年龄不匹配,患有乳腺癌的老年人有过度或不足治疗的风险.
准确评估生理年龄对于为70岁及以上的非转移性乳腺癌患者量身定制治疗至关重要.

研究的目的:

评估 70 岁及以上非转移性乳腺癌妇女生理年龄,时间年龄和治疗模式之间的关联.
为了确定脆弱性和预期寿命是否会影响老年乳腺癌患者的治疗决策.

主要方法:

对272名70岁以上的非转移性乳腺癌患者的回顾性分析,这些患者在10/2021-3/2024之间被诊断出非转移性乳腺癌.
利用了脆弱性 (老年人-8) 和预期寿命 (申伯格指数) 查数据.
多变量逻辑回归分析了HR+/HER2疾病亚组中预期寿命 (<10年) 和省略哨戒淋巴结活检 (SLNB) 和放射治疗 (RT) 之间的关系.

主要成果:

38.2%的查结果为虚弱阳性,23.5%的预期寿命小于10年.
与健壮患者 (11.9%) 相比,虚弱患者的预期寿命<10年 (42.3%) 的可能性要高得多.
经过调整后,预期寿命与在I-II期HR+/HER2-乳腺癌患者中省略SLNB或RT没有显著的关联.

结论:

在患有乳腺癌的老年女性中,脆弱性和有限的预期寿命很普遍,但可能不会显著地引导当前的治疗决策.
需要未来的研究和临床努力,以更好地将生理年龄的测量措施纳入对这一群体的治疗计划.

关键词:

乳腺癌乳腺癌乳腺癌脆弱脆弱脆弱脆弱脆弱老年病的治疗方法预期寿命预期寿命过度治疗过度治疗没有得到充分的治疗.

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