动物疾病生物标志物发现技术:机制,分类和诊断应用
Salwa Eman1, Raza Mohai Ud Din1, Muhammad Hammad Zafar1
1Collage of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Animals : an open access journal from MDPI
|November 13, 2025
概括
准确的动物疾病诊断依赖于生物标志物,生物标志物是健康状况的分子指标. 先进的技术对于发现和应用这些生物标志物对于更好的兽医诊断和疾病控制至关重要.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 生物标志物发现发现
- 分子诊断学 分子诊断
背景情况:
- 动物疾病对畜牧业生产率和公共健康产生重大影响.
- 准确和早期的诊断方法对于有效的疾病管理至关重要.
- 生物标志物作为兽医诊断中的关键分子指标,特别是当临床症状延迟或非特异时.
研究的目的:
- 审查兽医诊断,预后和预测生物标志物的分类和机制.
- 评估先进技术在生物标志物发现中的作用.
- 通过案例研究来说明生物标志物的应用.
主要方法:
- 关于生物标志物分类和机制的文献综述.
- 分析高通量欧米克平台:基因组学 (下一代测序,RNA测序),蛋白质组学 (液体染色学-质谱学/质谱学,差异凝电泳) 和代谢学 (核磁共振,液体染色学-质谱学/质谱学).
- 评估新兴技术,如CRISPR/Cas9,人工智能增强成像,基于aptamer的生物传感器和微流体设备.
主要成果:
- 高通量omics平台有效地识别特定疾病的分子特征.
- 新兴技术显示了兽医诊断的巨大潜力.
- 案例研究突出了生物标志物的实用应用在狗黑色素瘤,牛呼吸系统疾病综合体和先天性移植系统突变中.
结论:
- 将生物标记机制与先进的分析技术相结合,对于改善兽医诊断至关重要.
- 解决标准化,物种变异性和临床翻译等挑战是提高兽医疾病控制的必要条件.
- 生物标志物对于动物疾病的早期检测,预后和治疗反应监测至关重要.
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