由混合益生菌菌株发酵的可以缓解D-银糖诱导的小鼠骨肌肉和肠道衰老
Huixian Han1, Jin Tao1, Xiaoyue Bai2
1Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Foods (Basel, Switzerland)
|November 13, 2025
概括
百合发酵剂 (LF) 通过改善肌肉功能和肠道健康来对抗小鼠的衰老效应. 它减少了炎症,氧化应激,并恢复了肠道微生物群的平衡,为衰老提供了功能性食物的潜力.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 微生物学 微生物学
背景情况:
- 衰老与骨肌肉和肠道功能障碍有关.
- 慢性炎症,氧化应激和肠道失调是衰老的关键驱动因素.
- 制定干预措施以缓解与年龄相关的衰退至关重要.
研究的目的:
- 为了研究枝发酵剂 (LF) 对小鼠D-银糖诱导的衰老的保护作用.
- 评估LF对骨肌肉和肠道健康的影响.
- 探索LF抗衰老功能的潜在机制.
主要方法:
- 用混合微生物发酵制备的李子发酵剂 (LF).
- D-银河糖诱导衰老的小鼠模型.
- 评估肌肉功能,结肠过渡,衰老标志物,肠道组织学,炎症,氧化应激,微生物群组成和代谢学.
主要成果:
- 轻纤维改善了肌肉力量,耐力和纤维形态.
- 乳清缓解了结肠过境问题,减少了衰老标志物 (p16,p21) 和改善了肠道屏障功能 (MUC2,ZO-1,Claudin-1,Occludin).
- 肺炎降低了炎症 (IL-1β,IL-6,TNF-α),氧化应激 (MDA,GPx,SOD) 和调节了肠道微生物群 (Firmicutes/Bacteroidetes比率,有益的细菌).
结论:
- 百合发酵剂对骨肌肉和肠道表现出显著的抗衰老作用.
- 通过减少炎症,氧化应激和恢复肠道平衡,LF减轻了衰老.
- 富含酸和黄酸的LF显示出对抗衰老的功能性食物的希望.
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