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在胆道癌症中循环DNA的预后作用:系统性审查和元分析

Sara Boggio¹, Laura Alaimo¹, Edoardo Poletto¹

¹General and Hepato-Biliary Surgery Unit, Department of Surgery, Dentistry, Gynecology, and Pediatrics, University of Verona, University Hospital G.B. Rossi, P.le L.A. Scuro 10, 37134 Verona, Italy.

|November 13, 2025

概括

在胆道癌 (BTC) 中,循环瘤DNA (ctDNA) 检测和变异性基因频率 (VAF) 预测预后和死亡率不佳. 液体活检有助于风险分层和个性化治疗,以获得更好的患者结果.

科学领域:

在瘤学瘤学.
分子诊断学分子诊断
癌症生物标志物癌症生物标志物

背景情况:

胆道癌 (BTC) 是具有不良预后的侵袭性,需要早期检测和生物标志物.
液体活检,分析循环瘤DNA (ctDNA),正在成为BTC管理的关键工具.
非侵入性方法对于早期检测和指导治疗策略至关重要.

研究的目的:

评估ctDNA的预后价值作为BTC生存结果的预测指标.
评估ctDNA检测和变异性等位基因频率 (VAF) 在预测死亡率和疾病进展中的作用.
探索ctDNA和VAF作为治疗耐药性和个性化护理的生物标志物的潜力.

主要方法:

在PubMed,Cochrane图书馆和Wiley数据库中进行系统的文献搜索.
包括研究ctDNA与总生存 (OS),无进展生存 (PFS),无疾病生存 (DFS) 和无复发生存 (RFS) 相关的研究在BTC.
来自12项涉及2374名患者的研究数据的元分析.

主要成果:

ctDNA检测与增加的死亡率和疾病进展风险显著相关 (HR 2.61和HR 2.69).
更高的变异性等位基因频率 (VAF) 是死亡率和进展的强有力的预测指标 (HR 2.37和HR 2.22).
VAF的预测值独立于化疗,这表明它有可能作为治疗耐药性的标志物.

结论:

ctDNA状态和VAF对于BTC预后评估和管理具有临床意义.
液体活检集成可以改善BTC的风险分层和早期复发检测.
研究结果支持个性化治疗策略,以实现更有效的BTC患者护理.

关键词:

胆道癌症是胆道癌症.化学疗法化疗化疗 ctDNActDNA是什么意思液体活检活检液体活检长期的结果是长期的结果.

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