Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.3K
Relative Risk01:12

Relative Risk

1.8K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
1.8K
Polygenic Traits01:18

Polygenic Traits

68.8K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
68.8K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

392
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
392

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Alcohol-Related Frequent Attenders to Emergency Departments: A Scoping Review with Implications for Singapore.

Journal of clinical medicine·2026
Same author

Epstein-Barr virus antibodies and risk of non-Hodgkin lymphoma: a pooled analysis of four prospective cohorts.

Blood cancer journal·2026
Same author

History of blistering sunburns and keratinocyte carcinoma risk in a nationwide U.S. cohort.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2026
Same author

Genetic drivers of etiologic heterogeneity in thyroid cancer.

Nature communications·2026
Same author

Social isolation and overall well-being among cancer survivors in the Cancer Prevention Study-3.

Journal of cancer survivorship : research and practice·2026
Same author

Physical activity - Even at high volumes - Is associated with a lower risk of colon cancer.

Cancer epidemiology·2026

相关实验视频

Updated: Jan 11, 2026

Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.7K

在180,398名女性中,使用家族史,多基因风险得分和传统风险模型对乳腺癌高风险分类的值重叠.

Peh Joo Ho1,2, Christine Kim Yan Loo1, Ryan Jak Yang Lim1

  • 1Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672, Singapore.

Cancers
|November 13, 2025
PubMed
概括

多基因风险评分 (PRS) 提高了乳腺癌风险预测,特别是在年轻女性和亚裔女性中,超过了像盖尔模型这样的传统模型. 在不同的人群中,PRS在风险分层方面提供了附加值.

关键词:
这就是BRCA1的原因.这就是BRCA2的原因.盖尔 模型 模型 盖尔乳腺癌 乳腺癌 乳腺癌在位管道癌 (DCIS)多基因风险评分 (PRS)风险分层的风险分层.基于风险的查是基于风险的查.

更多相关视频

An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.5K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

633

相关实验视频

Last Updated: Jan 11, 2026

Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.7K
An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.5K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

633

科学领域:

  • 遗传学和基因组学 遗传学和基因组学
  • 癌症流行病学 癌症流行病学
  • 生物统计学 生物统计学

背景情况:

  • 传统的乳腺癌风险模型,如盖尔模型和多基因风险评分 (PRS) 提供独立的信息.
  • 这些模型在不同的祖先,年龄组和疾病类型中的重叠和性能变化仍然不清楚.

研究的目的:

  • 评估PRS和盖尔模型在预测乳腺癌风险方面的性能和重叠.
  • 评估模型性能如何根据祖先,年龄和疾病类型 (侵入性乳腺癌,DCIS) 变化.

主要方法:

  • 一项对180,398名女性 (欧洲和亚洲血统) 的回顾性病例控制研究.
  • 使用后勤回归模型来估计赔率比率 (ORs) 和接收器运行特征曲线 (AUC) 下的面积.
  • 分析包括根据年龄和祖先的相互作用,以及校准评估.

主要成果:

  • 在年轻的欧洲女性中,PRS的关联性更强 (AUC=0.622) 比较老 (AUC=0.653),亚洲女性的表现较低 (AUC=0.551-0.600).
  • 盖尔的模特表现整体上是温和的,在年轻的亚洲女性中表现不佳 (AUC=0.523-0.533).
  • PRS发现了更多高风险的亚洲人,而盖尔发现了更多高风险的欧洲人. 两种模型都显示了校准错误.

结论:

  • 多基因风险得分增强了传统模型之外的乳腺癌风险分层.
  • 对于年轻女性和亚洲血统的个人来说,PRS特别有价值.
  • 需要进一步的研究来解决模型校准错误,并改善跨不同人群的风险预测.