相关实验视频
Updated: Jan 11, 2026

08:30
MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
Published on: May 16, 2012
25.0K
CircATP2C1通过miR-654-3p介导的SLC7A11上调和ferroptosis抑制驱动前列腺癌的进展
Zhihai Deng1, Qiang Shen2, Nan Deng2
1Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Cancers
|November 13, 2025
概括
循环RNAcircATP2C1通过抑制细胞死亡过程ferroptosis促进前列腺癌的进展. 向circATP2C1为晚期前列腺癌提供了一个新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 前列腺癌是一种常见的男性泌尿生殖系统恶性瘤,晚期的存活率较低.
- 循环RNAs (circRNAs) 和铁亡与前列腺癌的进展有关,但它们的相互作用尚未得到充分理解.
研究的目的:
- 为了研究circRNAs在调节前列腺癌中的ferroptosis中的作用.
- 确定前列腺癌治疗的新型治疗点.
主要方法:
- 生物信息学分析和人类前列腺癌组织微阵列被用于探索circRNA表达特征.
- 莲氏病毒被用来构建稳定的circRNA-knockdown或过度表达的前列腺癌细胞系.
- 在AGO2-RNA免疫沉 (AGO2-RIP) 中发现了circRNA-microRNA (miRNA) 相互作用.
主要成果:
- 发现 circATP2C1 在前列腺癌组织中表达高.
- 通过抑制ferroptosis在体外,circATP2C1促进前列腺癌细胞的增殖,迁移和入侵.
- 在体内,circATP2C1通过抑制ferroptosis增强了前列腺癌的瘤性.
结论:
- circATP2C1通过通过海绵化miR-654-3p增加溶解物载体家族7成员11 (SLC7A11) 表达来抑制铁.
- circATP2C1在前列腺癌中起着致癌作用.
- circATP2C1代表前列腺癌的潜在治疗点.
关键词:
在CircATP2C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1C1在 SLC7A1111 中.铁性化 (ferroptosis) 是一种在 miR-654-3p 中使用.前列腺癌是前列腺癌.相关概念视频
mTOR Signaling and Cancer Progression
4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.6K
The Retinoblastoma Gene
4.6K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.6K
Abnormal Proliferation
5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K

