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α-二甲酸通过调节蛋白质平衡和优化线粒体功能来改善D-银糖诱导的老化小鼠中的肉症

Yangguang Zhang^1,2, Huihui Wang¹, Yijia Zhang³

¹Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.

|November 13, 2025

概括

阿尔法-谷氨酸 (AKG) 通过改善蛋白质平衡和线粒体功能来对抗与年龄相关的肌肉损失 (骨肉衰竭). 这项研究表明,AKG是肌肉衰老的潜在治疗方法.

科学领域:

老年学是一门学科.
生物化学生物化学
肌肉生理学肌肉生理学

背景情况:

萨科佩尼亚的特点是与年龄相关的肌肉质量,力量和功能的损失.
这种情况对老年人口的生活质量和流动性产生了重大影响.

研究的目的:

在老化小鼠模型中研究alpha-ketoglutaric acid (AKG) 的治疗潜力.
阐明AKG影响肉症的潜在机制.

主要方法:

通过使用8周大的雄性C57BL/6J小鼠建立了一个D-银糖诱导的肉症小鼠模型.
评估了AKG给药对肌肉质量,力量,运动耐力和耐寒性的影响.
分析了涉及蛋白质稳态,氧化应激和线粒体功能的分子机制.

主要成果:

在老年小鼠中,AKG治疗显著改善了肌肉质量,握力,运动耐力和耐寒性.
AKG增强了骨肌肉蛋白质稳态和肌纤维大小.
AKG增强了SOD活性,清除了活性氧物种 (ROS),并激活了SIRT1/PGC-1α/Nrf2通路,改善了线粒体功能.

结论:

AKG通过双重机制证明了对抗萨尔科佩尼亚的有效性:调节蛋白质平衡和优化线粒体功能.
这些发现支持AKG作为减轻与年龄相关的肌肉衰退的有希望的治疗剂.

关键词:

抗氧化作用抗氧化作用线粒体功能线粒体功能蛋白质的平衡是蛋白质的平衡.这种类型的麻症是sarcopenia.α-基格酸盐的使用.

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