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在患有乳头甲状腺癌的患者中遵守地中海饮食和一年的代谢变化:一项观察性研究
Jinyoung Shin1, Seok-Jae Heo2, Yae-Ji Lee3
1Department of Family Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 05030, Republic of Korea.
Nutrients
|November 13, 2025
概括
在被诊断为乳头甲状腺癌 (PTC) 患者的高地中海饮食 (MD) 坚持下,在一年内改善了胰岛素耐药性和HDL胆固醇. 这种饮食模式有利于甲状腺癌幸存者.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 在瘤学瘤学.
背景情况:
- 地中海饮食 (MD) 与一般人群的代谢益处有关.
- 有限的数据存在于MD对甲状腺癌幸存者的代谢健康的影响.
- 乳头甲状腺癌 (PTC) 患者的代谢变化需要进一步调查.
研究的目的:
- 评估PTC患者在诊断时的MD坚持和胰岛素抵抗和脂质配置文件的纵向变化之间的关联.
- 探索MD对代谢标志物的影响,包括BMI,HbA1c,HOMA-IR,METS-IR,HOMA-β和TyG指数.
- 调查这些关联中的潜在的BMI相关差异.
主要方法:
- 从2023年4月到2024年3月对345名韩国PTC患者 (年龄≥20岁) 的分析.
- 在诊断时使用韩国地中海饮食坚持选器评估的MD坚持,分类为三级动物.
- 从基线到诊断后一年的代谢变化的评估,用BMI分层分析.
主要成果:
- 一年后的随访显示,BMI,HbA1c,METS-IR,HOMA-β,甘油三,LDL-C和TyG指数显著降低,HDL-C增加.
- 与低坚持群体相比,高的MD坚持与降低的HOMA-IR和增加的HDL-C相关.
- 按BMI分层分析显示,胰岛素耐药性降低主要发生在患有高MD坚持的肥胖患者中.
结论:
- 在诊断时更高的MD坚持与改善的胰岛素耐药性标志物和PTC患者的HDL胆固醇增加有关.
- 在PTC幸存者诊断后的第一年,MD可能在管理代谢健康方面发挥有益作用.
- 专注于MD坚持的饮食干预措施对PTC幸存者,特别是那些患有肥胖症的人来说可能是有价值的.
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