果衍生的多和骨健康:一个系统性审查
Simone Perna1, Giorgia F Ruina1, Asmita Acharya1
1Department of Food, Environmental and Nutritional Sciences (DeFENS), Division of Human Nutrition, Università degli Studi di Milano, 20133 Milan, Italy.
Nutrients
|November 13, 2025
概括
果富含抗氧化剂,通过减少氧化应激和炎症来改善骨健康的潜力. 然而,需要更强大的临床试验来证实这些对骨质疏松症预防的好处.
科学领域:
- 营养科学 营养科学
- 骨生物学 骨生物学 骨生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨质疏松症的发病包括氧化应激和炎症.
- 果含有多,特别是,具有潜在的骨调节特性.
- 这次审查是第一个全面综合果和骨健康的证据.
研究的目的:
- 系统地审查和综合果和果衍生化合物对骨健康影响的证据.
- 使用GRADE框架整合人类,动物和体外数据.
- 评估果消费和骨结果的证据确定性.
主要方法:
- 在主要数据库 (PubMed,Embase,科学网,Scopus,Cochrane图书馆) 进行系统的文献搜索,直到2025年4月.
- 包括人类,动物和体外研究,调查果/化合物和骨结果.
- 偏差风险评估和人类证据的GRADE确定性评估.
主要成果:
- 包括19项研究 (包括5项人类研究,9项体内研究,5项体外研究).
- 观察数据表明,较高的安托西亚宁摄入与较高的骨矿物质密度 (BMD) 相对应.
- 有限的人体试验显示,对骨和骨周转标记物的影响很小;动物和体外研究表明,对骨质损失有保护作用.
结论:
- 果多可以通过抗氧化和抗吸收机制支持骨健康.
- 目前的临床证据受到小样本大小,异质性和缺乏骨折数据的限制.
- 为了制定饮食建议,需要进行更大规模的标准化随机对照试验 (RCT).
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