饮食模式,而不是肠道微生物组合,与自闭症儿童的行为挑战有关:一项观察性研究
Genna Di Benedetto1, Germana Sorge1, Marco Sarchiapone1
1Il Cireneo SRL, 66054 Vasto, Italy.
Nutrients
|November 13, 2025
概括
自闭症谱系障碍 (ASD) 与饮食有关,而不是肠道微生物. 患有自闭症的儿童表现出不同的饮食模式,影响他们的肠道微生物群,这表明行为影响微生物,而不是相反.
科学领域:
- 微生物组研究的研究.
- 神经发育障碍 神经发育障碍
- 人类肠道微生物组
背景情况:
- 自闭症谱系障碍 (ASD) 涉及社交沟通挑战和重复性行为.
- 肠-大脑轴与ASD有关,但人类研究有不一致的发现.
- 饮食和行为混了微生物组-ASD研究.
研究的目的:
- 研究ASD儿童的肠道细菌组和真菌组与兄弟姐妹和父母的对比.
- 评估ASD和非ASD个体的饮食摄入量.
- 确定饮食,微生物组和ASD诊断之间的关系.
主要方法:
- 在ASD儿童,非ASD兄弟姐妹和父母的肠道微生物组 (细菌组和真菌组) 的比较.
- 采集了详细的饮食摄入数据,使用7天的食物日记.
- 利用了多个王国微生物组的分析和统计分析.
主要成果:
- 在ASD,兄弟姐妹和父母组之间没有发现肠道微生物多样性 (α-或β-) 的显著差异.
- 饮食模式显著不同:自闭症儿童消费的糖果更多,蔬菜少,饮食多样性较低.
- 统计分析表明饮食因素,而不是微生物组成,解释了ASD诊断变化.
结论:
- 在ASD中选择性饮食行为塑造了饮食摄入量,影响了肠道微生物多样性.
- 人类的方向性似乎是行为 -> 饮食 -> 微生物组.
- 强调需要将饮食变量纳入微生物组研究,并考虑针对ASD的营养干预措施.
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