对微量营养素水平与围产期抑郁症之间的相关性进行系统审查
Nabilah Islam1, Annalese Semmler2, Jean Starling3
1Centre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
Nutrients
|November 13, 2025
概括
围产期抑郁症可能与微量营养素缺乏有关,特别是维生素D.需要进一步的研究来证实其他维生素和矿物质在母亲心理健康中的作用.
科学领域:
- 产科和妇科 产科和妇科
- 营养精神病学 营养精神病学
- 围产期心理健康 围产期心理健康
背景情况:
- 围产期抑郁症对母亲和儿童的福祉构成重大风险.
- 微量营养素失衡可能会影响神经递质合成和神经内分泌/神经免疫通路.
- 怀孕和产后期间生理需求增加增加了营养缺乏的风险.
研究的目的:
- 系统地审查和综合有关微量营养素水平与围产期抑郁症之间的联系的证据.
主要方法:
- 在六个主要数据库 (MEDLINE,EMBASE,PsycINFO,CINAHL,Scopus,Web of Science) 中进行全面的文献搜索.
- 包括使用经过验证的工具评估血液微量营养素水平和围产期抑郁症的研究.
主要成果:
- 在58项研究中,有31项发现围产期抑郁症与维生素D,铁,维生素B12,叶酸或缺乏之间存在显著联系.
- 维生素D是研究最多的营养素,出现在28篇文章中.
- 27项研究没有发现研究的微量营养素有显著的关联.
结论:
- 维生素D缺乏显示出与围产期抑郁症相关的最强有力的证据.
- 对其他微量营养素的证据仍然是混合的,不确定的或有限的.
- 需要进一步研究以阐明各种微量营养素在围产期抑郁症发展中的作用.
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