比较生物基光交联气凝的可打印性,生物和物理化学性质
Ane García-García1,2, Unai Silván2,3, Leyre Pérez-Álvarez1,2
1Innovative Macromolecular Materials Group (Imacromat), Physical Chemistry Department, Faculty of Science and Technology, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.
Polymers
|November 13, 2025
概括
这项研究开发了用于组织工程支架的新型基于生物的可光交联的水凝. 基于凝的水凝显示出卓越的可打印性和细胞附着性,显示出3D生物打印应用的巨大潜力.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 聚合物化学 聚合物化学
背景情况:
- 生物基光交叉链接的水凝模仿组织工程支架的细胞外基质 (ECM).
- 基于挤出的3D打印可以制造复杂的脚手架架构.
研究的目的:
- 开发和表征甲基烯化奇托,酸盐和基于凝的水凝,用于基于挤出的3D生物打印.
- 评估这些新型生物油墨的可打印性,机械性能,降解动力学和生物相容性.
主要方法:
- 基托,酸盐和凝聚合物的甲化.
- 基于挤出的3D打印水凝支架.
- 水凝形态的表征,胀,机械,质和降解性质.
- 使用骨髓衍生中酶干细胞 (BM-MSCs) 进行生物相容性评估.
主要成果:
- 所有开发的水凝都成功地通过光诱导的3D打印.
- 与甲基化酸盐相比,甲基化酸盐表现出增强的打印能力,形状忠实性和结构完整性.
- 水凝显示出良好的生物相容性,以凝为基础的配方显示出优异的BM-MSC附着和扩散.
- 鉴定发现了胀 (6-40%),机械性质 (Young的模量,0.1-0.5KPa),质性质 (300-1000Pa) 和降解动力学 (10-60天).
结论:
- 甲基烯酸凝水凝是基于挤出的3D打印的有前途的生物墨水,因为它具有卓越的打印能力和生物相容性.
- 基托桑,酸盐和基于凝的水凝显示出在组织工程中用于光诱导3D生物打印的生物材料的潜力.
- 进一步优化甲基化酸盐可能会提高其在3D生物打印中的应用性.
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