增材制造模仿心脏软组织的非线性机械行为
Sara Valvez1, M Oliveira-Santos2, L Gonçalves2
1University of Coimbra, Centre for Mechanical Engineering, Materials and Processes (CEMMPRE, ARISE), Department of Mechanical Engineering, 3030-788 Coimbra, Portugal.
Polymers
|November 13, 2025
概括
研究人员开发了3D打印模型来模仿左心房附属体 (LAA) 等软组织的复杂机械特性. 这一进步有助于为医疗应用创建现实的模型.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 机械工程 机械工程
背景情况:
- 软生物组织表现出复杂的非线性和异型机械特性,这些特性对生理功能至关重要.
- 通过增材制造在工程材料中复制这些特性对于生物医学应用,如手术模拟和设备开发至关重要.
- 左心房附属体 (LAA) 是一个关键的解剖结构,参与心房动期间的血栓形成,使其成为研究心血管疾病的相关模型.
研究的目的:
- 建立一个框架,利用3D打印模型复制软生物组织的非线性应力-应变行为.
- 调查增材制造在创建解剖学准确和功能代表软组织模型方面的潜力.
- 为了优化打印参数,以实现可靠的结构和机械性能,在3D打印软组织类型中进行3D打印.
主要方法:
- 选择两种聚合物,聚氨 (TPU) 和热塑性弹性体 (TPE),以它们的可调硬度和弹性而选.
- 进行了参数研究,以评估Shore A硬度,填充密度和外部外数量对3D打印模型拉伸性能的影响.
- 在印刷模型上进行了机械测试,以获得应力-张力曲线并评估它们的机械反应.
主要成果:
- 该研究成功地证明了使用3D打印复制软组织的非线性应力-应变行为特征的能力.
- 材料特性 (Shore A硬度) 和打印参数 (填充密度,外数量) 的参数变化显著影响了模型的拉伸性能.
- 选择的聚合物TPU和TPE被证明适用于创建具有可调整机械特性的软组织模型.
结论:
- 增材制造为软组织的解剖生殖提供了一种可行的方法.
- 开发的框架可以创建3D打印模型,复制本地软组织的功能机械特性.
- 这些先进的软组织模型具有在外科模拟,医疗器械开发和临床前测试中的应用潜力.
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