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呼吸异烯传感器基于石英增强的光声谱学光谱学

Fadia Abou Naoum¹, Diba Ayache¹, Tarek Seoudi¹

¹IES, Montpellier University, CNRS, 34090 Montpellier, France.

Sensors (Basel, Switzerland)

|November 13, 2025

概括

研究人员开发了一种新的呼吸传感器来检测异二烯,这是代谢和心血管疾病的关键生物标志物. 这项技术通过测量呼吸中异二烯水平的变化,为非侵入性疾病诊断提供了希望.

科学领域:

生物医学工程生物医学工程
分析化学分析化学
呼吸系统医学呼吸系统医学

背景情况:

异烯是人类呼吸中最丰富的内源碳化合物.
高水平的异烯与代谢和心血管疾病有关,使其成为潜在的生物标志物.
在诊断应用中,精确和灵敏地检测呼吸中的异二烯至关重要.

研究的目的:

为了呈现出在呼出的气息中检测到异烯的情况,使用非光束石增强光声谱法 (QEPAS) 方法.
通过数值模拟来评估干扰气体 (CO2和H2O) 的影响,并优化传感器参数.
评估传感器的性能及其检测呼吸中异二烯度变化的能力.

主要方法:

使用了光束外的石英增强光声谱学 (QEPAS).
采用了一种自制的量子级联激光器,发射在11.03微米.
进行了数值模拟,以评估干扰气体效应并优化激光调制.
在健康的志愿者身上进行呼吸测量.

主要成果:

在1秒的获取时间内,实现了接近220个百亿分量 (ppbv) 的检测极限.
获得了1.1×10-8 cm-1·W·Hz-1/2.2的正常化噪声等效吸收率 (NNEA).
在健康志愿者中,在中度体力炼后,观察到呼吸中异烯度显著增加 (从约250-350ppbv到约450-650ppbv).

结论:

偏光 QEPAS 方法可以在呼出的呼吸中灵敏地检测出异二烯.
开发的传感器显示了监测呼吸中异二烯水平所反映的生理变化的潜力.
这项技术可以为代谢和心血管疾病的非侵入性诊断铺平道路.

关键词:

这就是QEPASAS.呼吸分析呼吸分析异二烯是一种异二烯.摄影声学摄影声学

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