通过超选择性动脉旋转标记测量脑血管疾病的输液区域变化
Gabriel Hoffmann1,2, Miriam Reichert1, Jens Göttler1
1Department of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
概括
超选择性伪连续性动脉旋转标记 (ss-pCASL) 揭示了无症状内动脉狭窄症 (ICAS) 中的慢性缺血. 这种非侵入性MRI技术客观地量化了附带血流,为侵入性血管造影提供了替代方案.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 个性化诊断对于脑血管疾病至关重要,例如内动脉狭窄 (ICAS).
- 评估附带血液供应至关重要,但传统的数字减去血管造影 (DSA) 存在风险.
- 非侵入性MRI技术,包括超选择性伪连续动脉旋转标记 (ss-pCASL) 和4D-sPACK,提供了替代方案.
研究的目的:
- 使用ss-pCASL对无症状动脉样硬化引起的ICAS和莫亚莫亚病患者的附带血液流量进行定量评估.
- 与DSA相比,评估非侵入性MRI技术的诊断价值.
主要方法:
- 涉及ICAS,Moyamoya病和健康对照 (HCs) 患者的前性研究.
- ss-pCASL用于 perfusion 区域映射,分析体积,区域移动,图谱重叠和脑血流 (CBF).
- 在ICAS患者和组之间进行半球比较.
主要成果:
- 与HC相比,ICAS导致了半球体积的显著横向化,领土转移,亚特拉斯重叠和CBF.
- ss-pCASL证明了在无症状ICAS中长期失血的客观量化.
- 4D-sPACK的诊断价值与DSA相似,用于评估莫亚莫亚病的附带供应.
结论:
- ss-pCASL有效地绘制 perfusion 区域,揭示和量化无症状 ICAS 中的慢性 perf perfusion.
- 4D-sPACK提供了类似于DSA的诊断实用程序,用于评估附带血液供应.
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