疼痛机制和风湿性关节炎的管理策略
Dijun Wang1, Ting Li1, Weiqi Wang1
1Changzhou Key Laboratory of Human Use Experience Research & Transformation of Menghe Medical School, Changzhou Hospital Affiliated to Nanjing University of Chinese Medicine, Changzhou, China.
Frontiers in pain research (Lausanne, Switzerland)
|November 13, 2025
概括
风湿性关节炎 (RA) 疼痛管理是次优的,尽管治疗. 了解RA疼痛机制,包括炎症和神经免疫相互作用,是更好的诊断和向治疗的关键.
科学领域:
- 类风湿病学 类风湿病学
- 疼痛医学 医学 疼痛医学
- 免疫学 免疫学 免疫学
背景情况:
- 类风湿性关节炎 (RA) 是慢性疼痛的常见原因,目前的治疗方法往往产生不理想的疼痛管理结果.
- RA 疼痛是一种复杂的疾病,受炎症反应,神经免疫相互作用,神经敏感化,自身抗体和关节结构损伤的影响.
- 尽管存在止痛药,但许多RA患者仍然存在明显的疼痛,这凸显了对疼痛控制的未满足需求.
研究的目的:
- 综合审查和总结导致类风湿性关节炎疼痛的多面机制.
- 阐明炎症,神经免疫相互作用,自身抗体和结构损伤在RA病变和疼痛中的作用.
- 为改善RA引起的疼痛的诊断策略和有针对性的治疗干预提供基础.
主要方法:
- 对RA相关研究的文献综述,重点关注疼痛机制.
- 分析病理过程,包括炎症反应,神经免疫相互作用和神经敏感化.
- 检查自身抗体和关节结构损伤对RA疼痛的贡献.
主要成果:
- 炎症反应是RA疼痛的主要驱动因素.
- 神经免疫相互作用被确定为RA疼痛的中心机制.
- 自体抗体和关节结构损伤显著导致RA疼痛,特别是在后期阶段.
结论:
- 关节炎疼痛是一种复杂的过程,涉及多个相互关联的机制.
- 针对神经免疫相互作用,以及炎症,对于有效的RA疼痛管理至关重要.
- 对这些机制的进一步了解将促进精确的诊断和针对RA患者的量身定制的治疗策略.
相关概念视频
01:25Analgesia and Pain Management
1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
01:21Rheumatic Heart Disease III: Medical Management
272
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
272
01:44Nociception
33.0K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
33.0K
01:20Rheumatic Heart Disease IV: Nursing Management
256
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
256
01:23Peripheral Artery Disease V: Postoperative Nursing Management
360
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
360
01:26Peripheral Artery Disease IV: Nursing Management
329
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
329