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前列腺癌放射治疗后发生生殖尿路晚期影响的风险与膀形状的早期变化有关
Oscar Casares-Magaz1, Renata G Raidou2, Katarina Furmanová3
1Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Physics and imaging in radiation oncology
|November 13, 2025
概括
使用机器学习的早期膀形状分析可以预测前列腺癌放射治疗中的生殖尿路副作用. 这有助于识别患有这些晚期副作用的风险较高的患者.
科学领域:
- 在瘤学瘤学.
- 医疗成像医学成像
- 辐射疗法 辐射疗法
背景情况:
- 生殖尿路晚期效应是前列腺癌放射治疗中显著的剂量限制因素.
- 预测这些影响对于患者管理和治疗规划至关重要.
研究的目的:
- 评估放射治疗第一周的膀形状描述器是否可以识别可能经历生殖尿路晚期影响的患者.
- 应用形状分析和机器学习来进行早期风险分层.
主要方法:
- 分析了258名前列腺癌患者的队列,这些患者接受了形光束计算机断层扫描 (CBCT) 导向的放射治疗.
- 治疗第一周的膀轮被用来生成17维形状描述符,用于患者集群.
- 进行了统计分析 (ANOVA),以比较患有和没有尿生殖系统晚期影响 (≥2级) 的患者之间的描述值.
主要成果:
- 84%的膀在治疗初期可以分为两个不同的形状集群.
- 特定形状描述符 (凸度,圆差异,紧度) 在发生生殖尿路晚期影响的患者中显著不同 (p < 0.05).
- 使用周初描述符的预测模型实现了高准确性 (代数系数>93%).
结论:
- 在放射治疗的第一个星期进行膀形状分析,可以预测前列腺癌患者的尿生殖系统晚期影响.
- 早期识别高风险患者可以为治疗调整和支持性护理提供信息.
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