术前预后营养指数作为术后肺炎的预测因素,用于接受食道切除术的食道癌患者
1Department of Thoracic Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.
Frontiers in nutrition
|November 13, 2025
概括
术前预后营养指数 (PNI) 可以预测经过食道切除术的食道癌 (EC) 患者的术后肺炎 (POP). 结合PNI的诺米图表显示出对POP的预测具有很好的准确性,有助于临床决策.
科学领域:
- 在瘤学瘤学.
- 手术并发症 手术并发症
- 营养生物标志物 营养生物标志物
背景情况:
- 手术后肺炎 (POP) 是因为食道癌 (EC) 的食道切除术后的一个重要并发症.
- POP增加了患者的发病率,死亡率和医疗保健费用.
- 确定POP的预测因素对于改善患者的治疗结果至关重要.
研究的目的:
- 确定手术前预后营养指数 (PNI) 是否独立地预测EC患者的POP.
- 使用PNI开发和验证POP的预测模型.
主要方法:
- 分析了200名接受食道切除术的EC患者队列.
- 接收器操作特征 (ROC) 曲线分析评估了PNI的预测能力.
- 单变量和多变量逻辑回归确定了风险因素.
- 使用AUC,校准曲线和决策曲线分析 (DCA) 构建和验证了一个预测性诺莫格拉姆模型.
主要成果:
- 在200名患者中,73名 (36.5%) 患有POP.
- 手术前的PNI (≤49.6) 是POP的一个显著风险因素 (AUC=0.602).
- 多变量分析确定了瘤位置,住院,白血球,单细胞计数和PNI作为显著的风险因素.
- 纳入PNI的诺米图实现了POP预测的AUC为0.831.
结论:
- 手术前的PNI是EC患者中POP的重要预测因子.
- 开发的整合PNI的诺莫格拉姆模型显示出高准确性和临床实用性,用于预测POP.
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