相关实验视频
Updated: Jan 11, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
747
SH3BGRL2作为人类食道状细胞癌的重要瘤抑制剂和预后因素
Kaiyan Chen1,2, Rui Zhu3, Fanrong Zhang4
1Laboratory of Cancer Biology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Journal of thoracic disease
|November 13, 2025
概括
在食道状细胞癌 (ESCC) 中,SH3BGRL2被降低调节,作为瘤抑制剂. 更高的SH3BGRL2表达与更好的生存相关,为ESCC病变发生提供了新的见解.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 食道状细胞癌 (ESCC) 是一种具有不良预后的侵袭性癌症.
- 需要进一步阐明ESCC致癌和进展的分子驱动因素.
- 了解ESCC的分子机制对于开发向疗法至关重要.
研究的目的:
- 确定驱动ESCC进展的关键基因和分子机制.
- 研究SH3BGRL2在ESCC发育和患者结局中的作用.
- 探索SH3BGRL2作为ESCC的预后生物标志物的潜力.
主要方法:
- 用RNA测序来识别ESCC瘤与正常组织中差异表达的基因.
- 免疫组织化学 (IHC) 用于在247个ESCC样本中评估SH3BGRL2蛋白表达.
- 在体外和体内测试以确定SH3BGRL2在ESCC中的功能意义.
主要成果:
- 在ESCC组织中,SH3BGRL2在RNA和蛋白质水平上显著下调.
- 增加SH3BGRL2表达与更长的无病生存期 (DFS) 和整体生存期 (OS) 相关.
- SH3BGRL2作为ESCC患者的独立预后因素,可能通过EGR1通路抑制增殖.
结论:
- 在ESCC中,SH3BGRL2作为关键瘤抑制剂起作用.
- 对于ESCC患者来说,SH3BGRL2是显著的预后决定因素.
- 这项研究为ESCC病原体提供了新的见解,并确定了潜在的治疗点.
相关概念视频
02:23Abnormal Proliferation
5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
9.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.3K
01:20The Retinoblastoma Gene
4.6K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.6K
01:12Loss of Tumor Suppressor Gene Functions
5.8K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
5.8K
02:07Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
02:38Mitogens and the Cell Cycle
7.7K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.7K