年龄调整的内脏脂肪指数和阻塞性睡眠呼吸暂停之间的关联:基于NHANES 2015-2018年的研究
Jinzhan Chen1, Yijiao Xu1, Jiaxin Liu1
1Department of Pulmonary Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China.
Journal of thoracic disease
|November 13, 2025
概括
经年龄调整的内脏脂肪指数 (AVAI) 与阻塞性睡眠呼吸暂停 (OSA) 独立相关. 较高的AVAI水平增加了发展OSA的可能性,有助于风险评估.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 内分泌学 在内分泌学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种与肥胖相关的普遍睡眠障碍,影响睡眠质量和日常功能.
- 准确的OSA风险评估对于及时干预和管理至关重要.
- 内脏脂肪,一种代谢功能障碍的标志物,涉及到OSA的发病.
研究的目的:
- 引入和评估年龄调整的内脏脂肪指数 (AVAI) 作为阻塞性睡眠呼吸暂停 (OSA) 风险的新标记.
- 调查AVAI与OSA在大量成年人群中的患病率之间的关联.
- 探索AVAI在识别患有OSA风险较高的个体方面的潜力.
主要方法:
- 利用了2015-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 使用多变量逻辑回归和倾向得分匹配 (PSM) 来分析AVAI和OSA之间的关联.
- 进行了子组和接收器运行特征 (ROC) 曲线分析,以评估效果修改和区分能力.
主要成果:
- 在AVAI和OSA之间发现了显著的关联 (OR=1.15,95%CI:1.09,1.21).
- 与最低四分位数相比,最高AVAI四分位数中的个体患OSA的可能性增加了2.67倍.
- 在PSM调整后,这种关联仍然显著,在女性和没有高血压,糖尿病或心血管疾病的人群中尤为明显.
结论:
- 经年龄调整的内脏脂肪指数 (AVAI) 与阻塞性睡眠呼吸暂停 (OSA) 独立相关.
- AVAI可以作为一种有价值的临床工具,用于识别患有OSA高风险的个人.
- 需要进一步验证以确定AVAI在临床实践中的预测效用.
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