女性性对艾滋病毒感染者的大量横截面队列中具有临床显著纤维化症的MASLD有保护作用
Kara Wegermann1, Ayako Suzuki2, Elisa Sarmiento3
1Division of Gastroenterology, Department of Medicine, Duke University Health System, Durham, NC, USA.
Open forum infectious diseases
|November 13, 2025
概括
与显著纤维化相关的代谢功能障碍相关的脂肪性肝病在感染艾滋病毒的妇女中较少见. 患有糖尿病,高脂血症和更大的腰围的男性需要进行MASLD查.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染病 (艾滋病毒/艾滋病)
- 代谢综合征是代谢综合征的一种.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 与临床显著的纤维化 (CSF) 影响男性比女性更多.
- 关于MASLD在艾滋病毒感染者 (PWH) 中的患病率和严重程度的数据有限.
- 这项研究调查了按性别和更年期状态分层的PWH中的MASLD-CSF.
研究的目的:
- 确定MASLD-CSF在艾滋病毒感染者 (PWH) 中的患病率和严重程度.
- 分析基于出生时分配的性别和更年期状态的MASLD-CSF差异.
- 为了确定PWH中MASLD-CSF的风险因素.
主要方法:
- 对HIV NASH CRN队列的横截面分析.
- 纳入标准:被抑制的HIV-1RNA,自我报告的性别和更年期状态,过渡性弹性图 (TE).
- 按受控减弱参数 (CAP ≥263dB/m) 和≥1心脏代谢风险因子定义的MASLD;通过TE肝硬度测量 (≥8kPa) 定义的CSF.
主要成果:
- 包括964个PWH:709名男性 (73.5%) 和255名女性 (26.5%).
- 与男性 (10.6%) (P = .02) 相比,女性中MASLD-CSF的发病率较低 (5.5%).
- 糖尿病 (OR 3.26),高脂血症 (OR 1.97) 和高腰围 (OR 4.59) 增加了MASLD-CSF的几率;女性性别是保护性的 (OR 0.43).
结论:
- 在艾滋病毒感染者中,女性性对MASLD-CSF有保护作用.
- 患有糖尿病,高脂血症和高腰围的男性应接受MASLD的查.
- 需要进一步的研究,特别是包括更多的妇女,特别是年轻的妇女,感染艾滋病毒.
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