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甲状腺功能激素与年龄相关的变化表明前列腺癌的风险:来自全国代表性数据集的证据
Yanjun Chu1, Dapeng Zhang2, Yujie Feng3
1College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Translational andrology and urology
|November 13, 2025
概括
甲状腺激素水平与前列腺癌 (PCa) 风险有关,特别是在老年人中. 某些甲状腺激素也可能在年轻男性中发出早期PCa风险的信号,前列腺特异性抗原 (PSA) 水平表明了这一点.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 老年医学 老年医学
背景情况:
- 前列腺癌 (PCa) 的风险随着年龄的增长而增加,并受到荷尔蒙失衡的影响.
- 内分泌干扰剂,特别是甲状腺激素,可能在PCa发展中发挥作用.
- 了解甲状腺功能和PCa之间的关系对于早期检测和预防策略至关重要.
研究的目的:
- 研究不同年龄组甲状腺功能激素变化与前列腺癌 (PCa) 风险之间的关联.
- 探索甲状腺激素水平和前列腺特异性抗原 (PSA) 水平与PCa.相关的相关性.
- 为了确定甲状腺激素失衡是否有助于PCa风险,以剂量依赖或年龄特定的方式.
主要方法:
- 从国家健康和营养检查调查 (NHANES) 2007-2010周期的数据分析.
- 血清甲状腺功能测试 (总三甲状腺素,自由三甲状腺素,总甲状腺素,自由甲状腺素,TSH) 通过免疫酶测试进行分析.
- 权重多变量后勤回归模型用于评估甲状腺激素水平与PCa/高度可能的PCa风险之间的关系,考虑到年龄和PSA水平.
主要成果:
- 在65岁以上 (12.13%) 和65岁以下 (1.52%) 的成年人中,PCa患病率为5.35%,显著高于65岁以上 (12.13%).
- 在老年人中,增加的总三甲氨酸 (TT3) 和自由三甲氨酸 (FT3) 与增加的PCa风险有关 (分别为OR=1.481,P<0.001和OR=1.452,P<0.001).
- 增加的总甲状腺素 (TT4) 和自由甲状腺素 (FT4) 与在没有甲状腺素的人中更高的高概率PCa风险相关,这表明年轻 (<65岁) 和老年 (≥65岁) 个体的早期风险分别较高. 较高的TSH与增加的PSA比率有关,而TT3 / FT3显示了与PSA水平的逆年龄相关联.
结论:
- 甲状腺功能激素水平与前列腺癌风险有显著的关联,特别是在老年人群中.
- 甲状腺激素的变化可以作为潜在的生物标志物,用于在年轻人和老年人中早期检测PCa风险,如PSA水平所示.
- 进一步研究甲状腺激素与前列腺癌发展之间的机制联系是有必要的,以告知临床实践和治疗策略.
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