在非手术管理的前列腺腺癌中,个性化放射治疗的益处预测:生存风险分层的预后名谱
Lang Wang1, Yong Shi1,2, Can Wei1
1Department of Urology, The Second People's Hospital of Hefei, Hefei, China.
Translational andrology and urology
|November 13, 2025
概括
放射治疗可以改善高风险前列腺癌患者的生存率,但不能改善低风险患者的生存率. 这项研究开发了一个名图,以识别从放射治疗中受益的前列腺腺癌 (PCa) 亚组.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 前列腺癌研究 研究前列腺癌
背景情况:
- 前列腺腺癌 (PCa) 是一个重大的全球健康挑战.
- 放射治疗是非手术治疗的PCa患者的关键治疗方法.
- 缺乏对放射治疗生存益处的预测工具.
研究的目的:
- 为非手术治疗的PCa患者制定风险分层模型.
- 在PCa中评估放射治疗的生存益处.
- 确定可能从放射治疗中受益的患者子组.
主要方法:
- 使用了SEER数据库 (2004-2015年100,155名患者).
- 使用回归分析构建了总生存率 (OS) 和癌症特异性生存率 (CSS) 的名图.
- 将患者分为低风险和高风险组进行分层分类,以进行子组分析.
主要成果:
- 在整体队列中,放射治疗改善了5年的OS和CSS.
- 接受放射治疗的高风险患者表现出显著的OS和CSS改善 (10.1%和10.2%).
- 低风险患者没有显示CSS的好处,并且在放射治疗后潜在的OS下降.
结论:
- 开发出来的诺米图准确地识别了从放射治疗中受益的患者.
- 高风险的PCa患者从放射治疗中获得了显著的生存益处.
- 对于低风险的PCa患者,不建议进行放射治疗.
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