相关实验视频
Updated: Jan 11, 2026
06:39
Real-Time Void Spot Assay
Published on: February 10, 2023
2.5K
初潮早期年龄与女性膀过活的风险之间的关联:来自NHANES和孟德尔随机分析的见解
Guoqiang Huang1, Kaiwen Xiao1, Shuangquan Lin1
1Department of Urology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Translational andrology and urology
|November 13, 2025
概括
初潮的早期年龄 (AAM) 与过度活跃的膀 (OAB) 风险增加有关,身体质量指数 (BMI) 起着调解作用. 控制体重和对AAM进行查可能有助于减少OAB发生率.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 初潮的早期年龄 (AAM) 与不良的代谢变化有关.
- AAM,过度活跃的膀 (OAB) 和体重指数 (BMI) 之间的关系需要进一步研究.
- 了解这些联系对于制定有针对性的预防策略至关重要.
研究的目的:
- 为了调查AAM和OAB风险之间的关联.
- 量化BMI在AAM-OAB关系中的调解作用.
- 使用孟德尔随机化 (MR) 评估AAM和OAB之间的因果关系.
主要方法:
- 分析了国家健康和营养检查调查 (NHANES) 中9,647名妇女的数据.
- 后勤回归和受限立方线 (RCS) 分析以评估AAM-OAB关联.
- 用156个SNP来对BMI的作用进行调解分析和因果关系的门德尔随机化 (MR).
主要成果:
- 一年增加的AAM与OAB风险下降5%相关 (OR:0.95,P<0.001).
- 体重指数介于AAM-OAB关联的30.89%.
- MR 分析为 AAM-OAB 联系 (OR:0.998,P=0.008) 提供了因果关系证据,没有显著的 pleiotropy.
结论:
- 早期的AAM因果关系与OAB风险增加有关,部分由BMI调解.
- 早期AAM查和体重管理是减少OAB风险的潜在策略.
相关概念视频
01:21Nursing Assessment of the Genitourinary System I: Health History
362
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
362
01:26The Micturition Reflex
2.4K
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
2.4K
01:30Bulimia Nervosa
661
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
661
01:28Menopause
3.5K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
3.5K
01:23Urinary Bladder
3.0K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.0K
01:30Attention-Deficit/Hyperactivity Disorder
725
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
725