在一个脂质体输送系统中与纳米颗粒结合的levothyroxine用于甲状腺功能低下症
Eylül Atan1,2, Güliz Ak1
1Department of Biochemistry, Faculty of Science, Ege University, İzmir, Turkiye.
Turkish journal of chemistry
|November 13, 2025
概括
这项研究开发了一种新的PEG-ylated脂质体输送系统,用于levothyroxine和纳米颗粒 (SeNPs),以增强甲状腺功能低下症的治疗. 该系统提高了口服生物可用性,并提供可控的药物释放,以获得更好的治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 利沃甲状腺素是甲状腺功能低下的主要治疗方法,但其口服生物可用性较差.
- (Se) 和它的纳米粒子 (SeNPs) 对于甲状腺功能调节至关重要.
- 脂质体输送系统,特别是PEGylated系统,提高药物的生物可用性和控制释放.
研究的目的:
- 开发一种口服适用的脂质体输送系统,用于levothyroxine和SeNPs.
- 为了提高levothyroxine和SeNPs的生物可用性.
- 为了实现对levothyroxine的控制释放,以加强甲状腺功能低下症的治疗.
主要方法:
- 通过使用 Askorbic 酸的水热方法合成的 SeNPs.
- 使用薄膜技术制备的脂质体,并装有levothyroxine和SeNPs.
- 用于口服应用的脂质体的PEGylation;使用FTIR,光谱测量和ICP-MS进行表征.
主要成果:
- 测量了75-100nm的SeNPs,具有特有的FTIR峰值.
- 利沃提素封装效率达到了91.4%.
- 观察到受控和恒定的levothyroxine释放,在pH 6.8时高于pH 7.4.
结论:
- 开发了一种成功的PEG涂层脂肪体输送系统,用于levothyroxine和SeNPs.
- 这个系统显示了增强甲状腺功能低下症的口服治疗的前景.
- 该方法提供了改善的生物可用性和受控的药物释放.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
7.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.1K
The Thyroid Gland
6.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.6K
Functions of Thyroid Hormones
4.9K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
4.9K


