压力,压力管理和痴呆症:叙述性审查
Arunima Chaudhuri1,2, Dharmendra K Gupta1
1Physiology, Burdwan Medical College, Burdwan, IND.
Cureus
|November 13, 2025
概括
慢性压力是痴呆症的一个显著可改变的风险因素,可能加速认知能力下降. 减少压力的干预措施对保持大脑健康和认知功能的有希望.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 痴呆症是一个日益严重的全球健康危机,年龄和遗传是主要的风险因素.
- 慢性压力是一种新兴的可修改的风险因素,与加速认知衰退和痴呆风险增加有关.
- 中年压力暴露与晚年痴呆症风险特别相关.
研究的目的:
- 探索慢性压力和痴呆症之间的联系.
- 审查将压力与痴呆症联系在一起的生物机制.
- 评估压力减轻干预措施对认知健康的潜力.
主要方法:
- 关于压力和痴呆风险的人口研究的综述.
- 对将压力激素 (如皮质醇) 与神经炎症和氧化损伤联系起来的生物途径的分析.
- 对减轻压力技术 (如正念,CBT) 的干预研究的评估.
主要成果:
- 慢性压力会破坏应激反应系统,提高皮质醇,并促进大脑炎症,氧化损伤和血液流动受损.
- 人口研究表明中年压力,抑郁症和痴呆风险增加之间存在关联.
- 减少压力的干预措施显示了压力水平,情绪,弹性和一些生物标记的改善,具有初步的认知益处.
结论:
- 慢性压力是痴呆的重要,可修改的风险因素.
- 应将压力管理纳入医疗保健和公共卫生战略,以维护认知健康.
- 需要对文化上适当的,长期的干预措施和多样化的人口进行进一步的研究.
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