在癌症幸存者中增加心血管风险,出现胸痛
Kobi Faierstein1,2, Rotem Tal-Ben Ishay2,3, Ranel Loutati1
1Leviev Cardiovascular Institute, Sheba Medical Center, Emek HaEla St. 2, Ramat-Gan 5262000, Israel.
European heart journal open
|November 13, 2025
概括
癌症史显著增加了心血管诊断的风险,患者呈现胸痛. 与其他患者相比,癌症幸存者面临心血管事件和死亡率更高的可能性.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 心血管疾病是全球死亡的主要原因之一.
- 癌症幸存者可能面临独特的健康挑战,包括增加心血管风险.
- 胸痛是一种常见的症状,需要准确的诊断.
研究的目的:
- 研究胸痛患者的个人癌症史和心血管诊断之间的关联.
- 为了量化癌症幸存者出现胸痛的心血管结果的风险.
主要方法:
- 对37819名住院患有胸痛的成年患者 (2007-2022) 的回顾性分析.
- 排除患有活跃癌症或ST升高心肌梗塞的患者.
- 主要结局:综合性心血管诊断 (非ST升高的心肌梗塞,肺栓塞,新发性心房动或30天死亡率).
- 统计分析包括多变量逻辑回归和倾向得分匹配.
主要成果:
- 5%的患者 (1838) 有癌症病史.
- 癌症幸存者患初级心血管终点的可能性增加了70% (逻辑回归,P < 0.001).
- 倾向性得分匹配显示,癌症幸存者的可能性增加了40% (95% CI 1.2-1.7,P < 0.001).
- 癌症幸存者死亡的累积概率明显更高 (29%对12%,P<0.001).
结论:
- 个人癌症病史独立地与胸痛患者心血管诊断的可能性更高有关.
- 患有胸痛的癌症幸存者需要仔细评估心血管风险.
- 这种关联凸显了癌症史对心血管的长期影响.
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