相互作用的神经群体之间的零相延迟同步:对功能连接性衍生生物标志物的影响.
Chirag Mehra1, Ahmad Beyh1,2, Petroula Laiou3,4
1Department of Forensic and Neurodevelopment Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Imaging neuroscience (Cambridge, Mass.)
|November 13, 2025
概括
在功能连接性分析中排除零相延迟连接可能会排除真正的神经相互作用. 包括这些连接提高了可靠性和生物相关性,挑战了当前的方法.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 生物标志物 生物标志物
背景情况:
- 神经活动与零或非零相延迟同步.
- 在电脑学 (EEG) 和磁脑学 (MEG) 中,零相延迟连接可能是人工的.
- 目前的方法不包括零相延迟交互来最大限度地减少文物,可能会丢失真正的连接数据.
研究的目的:
- 研究排除零相延迟相互作用对功能连接指标的影响.
- 确定零相延迟连接是否代表真实的神经相互作用.
- 评估包括零相延迟连接在功能连接指标作为生物标志物的性能上的影响.
主要方法:
- 使用电脑学和磁脑学数据分析皮层-皮层功能连接.
- 功能连接指标的比较,包括零相延迟相互作用和不包括零相延迟相互作用.
- 评估结构功能一致性,同位素半球间连接性和与年龄相关的变化.
主要成果:
- 大多数皮层-皮层功能连接都以零或接近零的相位延迟发生,即使不是人工.
- 包括零相延迟连接可以提高功能连接指标的可靠性,神经生物学融合和预后能力.
- 排除零相延迟连接不成比例地影响了结构上紧密相连的地区之间的连接.
结论:
- 零相延迟相互作用是真正的神经连接的重要组成部分.
- 目前排除零相延迟连接的做法可能会阻碍功能连接指标作为生物标志物的实用性.
- 这些发现挑战了假设零相排他性方法优于包容性方法的假设.
相关概念视频
02:47The Synapse
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
01:26Chemical Synapses
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
01:26Chemical Synapses
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...