胰岛素对肉中脂聚糖诱导的氧化应激的保护作用
Qinghui Shang1, Hao Li1, Yan Han1
1Shandong Provincial Key Laboratory of Livestock and Poultry Breeding, Poultry Institute, Shandong Academy of Agricultural Sciences, Jinan, China.
Frontiers in veterinary science
|November 13, 2025
概括
肉饮食中的胰岛素补充剂有助于防止由脂多糖 (LPS) 引起的氧化应激. 这种料添加剂提高肉的抗氧化能力,使其成为禽类健康的有希望的选择.
科学领域:
- 动物科学动物科学
- 禽类的营养 养
- 氧化压力研究研究 氧化压力研究
背景情况:
- 脂聚糖 (LPS) 是一种强烈的内毒素,可在肉中诱导显著的氧化应激.
- 氧化应激通过破坏细胞组件,对肉的健康,生长和肉质产生负面影响.
- 确定有效的策略来缓解LPS诱导的氧化应激对于家禽业至关重要.
研究的目的:
- 为了研究饮食中的胰岛素对肉中LPS诱导的氧化应激的保护作用.
- 确定胰岛素补充剂对抗氧化酶活性和脂质过氧化对LPS.挑战的 brojlers的影响.
- 阐明Nrf2信号通路在调解胰岛素保护作用中的潜在作用.
主要方法:
- 总共使用了108个Arbor Acres肉,分为三个组:控制 (CON),LPS挑战 (LPS) 和LPS挑战与胰岛素补充剂 (LPS+胰岛素).
- 鸟类被食基本饮食,LPS组接受LPS挑战,LPS+胰岛素组接受LPS挑战和15g/kg胰岛素.
- 测量包括抗氧化酶活性,血清,肝脏,肠道和肌肉中的脂质过氧化水平,以及对Nrf2信号通路的分析.
主要成果:
- 使用LPS显著降低了抗氧化酶的活性,并在各种组织中增加了脂质过氧化.
- 食用胰岛素补充剂部分改善了LPS对抗氧化能力的不良影响.
- 胰岛素的保护机制似乎涉及对Nrf2信号通路的调节.
结论:
- 胰岛素补充剂有效地缓解了肉中脂聚糖类诱导的氧化应激.
- 胰岛素显示出作为一种有益的料添加剂的潜力,可以增强肉对氧化挑战的抵抗力.
- 进一步研究胰岛素在家禽营养和健康中的作用是有必要的.
相关概念视频
Cell Specific Gene Expression
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Hormones Regulating Blood Glucose
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
Glucose Homeostasis: Regulation of Blood Glucose
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are co-secreted in...
Insulin and C-peptide are co-secreted in...
Oral Hypoglycemic Agents: Biguanides and Glitazones
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood glucose levels...
Dipeptidyl Peptidase 4 Inhibitors
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a significant...


