相关实验视频

Updated: Jan 11, 2026

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Published on: July 21, 2023

调节亡的微RNA和用于治疗椎间盘退化症的输送策略

Yuwei Chen^1,2, Chuan Guo¹, Weiqiang Lan¹

¹Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Frontiers in cell and developmental biology

|November 13, 2025

概括

椎间盘退化 (IDD) 是腰部疼痛的一个原因,可以通过使用微RNA (miRNA) 的基因疗法来治疗,以防止细胞死亡. 先进的传递系统提高了IDD治疗的miRNA有效性.

科学领域:

对于肌肉骨疾病的再生医学和基因疗法.

背景情况:

椎间盘退化 (IDD) 是慢性腰部疼痛 (LBP) 的主要原因,导致显著的生活质量下降和社会经济影响.
目前IDD的治疗方法是缓解性,无法解决根本原因或恢复椎间盘 (IVD) 功能.
核细胞 (NPC) 的亡是IDD病变发生的一个关键因素.

研究的目的:

审查抗亡微RNAs (miRNAs) 在调节NPC亡中的作用.
总结针对治疗IDD的治疗miRNA的向和响应性传递策略的进展.

主要方法:

对基于miRNA的IDD基因疗法的当前文献的综述.
对NPC向策略的分析,包括直接吸收,配体-受体相互作用和体利用.
对有机体向 (线粒体,ER) 和响应性传递系统 (刺激响应释放) 的评估.

主要成果:

抗亡miRNAs显示了缓解NPC亡的潜力,这是IDD的一个关键步骤.
向策略显著提高了miRNA向向细胞传递的有效性.
响应性传递系统允许对治疗性miRNAs进行控制的时空释放.

结论:

使用抗亡miRNAs的基因疗法为IDD提供了一个有前途的治疗途径.
新型向和响应性交付策略对于克服IVD基因疗法的挑战至关重要.
这些进展为开发有效的IDD和相关LBP治疗提供了新的见解.

关键词:

灭症 (apoptosis) 是一种死亡的过程.交付策略的交付策略椎间盘退化椎间盘退化这是一个微型RNA.细胞核细胞核细胞核

更多相关视频

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

Published on: August 10, 2018

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Published on: July 8, 2021

相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...