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衰老:一个被忽视的VSMC表型和治疗机会?

Allison B Herman¹, Katarina Gresova^2,3, Manolis Maragkakis⁴

¹Laboratory of Cardiovascular Science (A.B.H.), National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD.

Arteriosclerosis, thrombosis, and vascular biology

|November 13, 2025

概括

血管光滑肌细胞 (VSMCs) 可以进入衰老状态,这是一个独特的细胞状况. 本综述探讨了老化是否是VSMC的表型状态及其对心血管疾病的治疗潜力.

科学领域:

血管生物学血管生物学
细胞衰老细胞衰老
心血管疾病病理生理学病理生理学

背景情况:

血管光滑肌细胞 (VSMCs) 表现出表型可塑性,在静止状态和合成状态之间切换.
衰老是一种具有明显分泌表型的不可逆转细胞周期停止的细胞状态.
衰老在VSMC表型调节中的作用,特别是在心血管疾病中,尚未得到充分探索.

研究的目的:

研究衰老作为VSMCs潜在的表型状态.
将VSMC衰老的分子机制与调节VSMC可塑性的分子机制进行比较.
探索扭转VSMC衰老的潜力,以获得治疗效益.

主要方法:

关于VSMC衰老的分子机制的最新发现的审查.
将VSMC衰老与VSMC表型可塑性机制进行比较.
对转录基因数据库进行分析,以评估VSMC命运可塑性.

主要成果:

衰老是一种独特的细胞状态,其特点是细胞循环停止和特定的分子通路.
VSMC衰老与VSMC表型调节的已知机制有相似之处和对比.
转录基因数据表明,衰老的VSMC可能是可逆或中间细胞命运.

结论:

衰老可能代表VSMCs的一个独特的表型状态,而不仅仅是终端终点.
了解VSMC衰老机制为动脉样硬化,动脉化和大动脉动脉瘤提供了潜在的治疗点.
对逆转VSMC衰老的进一步研究可能导致新的心血管疾病治疗方法.

关键词:

动脉样硬化动脉样硬化细胞衰老细胞衰老冠状动脉血管冠状动脉血管血液动力学血液动力学肌肉,光滑的,血管的肌肉.血管改造血管改造血管改造

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