在心血管疾病的饮食和训练免疫力
Niels P Riksen1, Quirijn de Mast1
1Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Arteriosclerosis, thrombosis, and vascular biology
|November 13, 2025
概括
饮食习惯显著影响训练有素的免疫力,一种高反应性免疫状态. 特定的饮食和成分可以重编程免疫细胞,影响动脉样硬化发展,并可能预防心血管疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 心血管研究研究心血管研究
背景情况:
- 天生的免疫细胞可以通过代谢和表观遗传重编程获得持久的超响应状态,称为训练免疫.
- 训练有素的免疫力与加速动脉样硬化发展有关.
研究的目的:
- 审查当前关于饮食和特定饮食成分如何调节训练免疫力的证据.
- 探索饮食干预措施在预防心血管疾病方面的潜力.
主要方法:
- 对小鼠实验研究和人类干预研究的综述.
- 对饮食成分的ex vivo研究的分析.
- 检查髓状细胞和脂肪细胞中的表观遗传重编程.
主要成果:
- 间歇性高脂肪饮食和小鼠饮食诱导的肥胖会促进高炎症性免疫细胞,恶化动脉样硬化.
- 高血糖和高盐饮食在小鼠模型中诱导训练免疫力.
- 西式饮食会引发炎症,而植物性饮食会限制炎症,部分是通过训练有素的免疫调节.
- 饮食成分,如阿皮基宁和白醇,可以在体外防止训练免疫力.
结论:
- 饮食和特定的营养素可以显著调节训练有素的免疫力.
- 饮食干预有潜力通过准训练有素的免疫力来预防心血管疾病.
- 为了优化饮食策略,需要进一步研究分子机制.
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