通过使用代币化免疫注册表来提高COVID-19疫苗有效性的证据生成
Kathleen M Andersen1, Leah J McGrath1, Kristen E Allen1
1Pfizer Inc., New York, New York.
American journal of epidemiology
|November 13, 2025
概括
将州疫苗注册表与索赔数据整合起来,显著改善了COVID-19疫苗接种记录. 这种增强的数据捕获提供了更准确的疫苗有效性见解.
科学领域:
- 公共卫生 公共卫生
- 医疗信息学 医疗信息学
- 免疫研究 免疫研究
背景情况:
- 准确跟踪COVID-19疫苗接种率对于公共卫生监测和政策至关重要.
- 单靠行政索赔数据可能会低估疫苗覆盖率.
- 国家疫苗注册表提供了更全面的疫苗接种记录.
研究的目的:
- 引入一个新的数据生态系统,将索赔与注册表数据联系起来.
- 通过这种综合方法量化记录的COVID-19疫苗接种率的改善.
- 为了比较不同COVID-19疫苗配方的疫苗捕获率.
主要方法:
- 取消识别的行政索赔数据被令牌化并与国家疫苗注册表数据联系起来.
- 用单独的索赔数据与补充注册表数据的索赔数据来衡量疫苗接种率.
- 分析包括原始野生型,BA.4/5适应双价和XBB.1.5-适应的COVID-19疫苗配方.
主要成果:
- 整合增加了记录的原始野生类型系列从20%增加到57%.
- 适应BA.4/5的双价疫苗和适应XBB.1.5的疫苗的捕获量分别从7%增加到10%和6%增加到8%.
- 索赔数据主要通过药物代码捕获疫苗接种,而医疗补助保险人员的代表性较低.
结论:
- 添加州疫苗注册表显著提高了COVID-19疫苗捕获率 (野生类型的高达182%).
- 将索赔数据标记化到疫苗登记册中,可以更精确地估计疫苗的接种率和有效性.
- 这种新型数据生态系统增强了针对疫苗接种运动的公共卫生监测能力.
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