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在PSA水平和骨转移体积之间的不一致与不良的预后有关

Tomoki Shirafuji¹, Yasutaka Yamada¹, Kodai Sato¹

¹Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.

BJU international

|November 13, 2025

概括

骨扫描指数/初始前列腺特异抗原比率可以预测前列腺癌患者的存活率. 较高的比率表明风险更大,有助于转移性前列腺癌的个性化治疗策略.

科学领域:

在瘤学瘤学.
医疗成像医学成像
生物标志物生物标志物

背景情况:

具有骨转移的前列腺癌 (PCa) 是一个重大的临床挑战.
准确的预后标记是指导激素敏感PCa治疗决策的关键.
前列腺特异性抗原 (PSA) 水平与骨转移负担之间的关系并不总是直接的.

研究的目的:

评估骨扫描指数 (BSI) 与初始PSA (iPSA) 比率作为生物标志物的有用性.
评估激素敏感PCa和骨转移患者的BSI/iPSA比率的预后意义.

主要方法:

对526名骨转移性PCa患者的回顾性分析.
评估癌症特异性存活率和整体存活率 (OS).
应用多变量考克斯回归,卡普兰-梅尔,生存树分析和倾向-得分匹配 (PSM).

主要成果:

生存树分析发现0.02是BSI/iPSA比率的最佳切断值.
较高的BSI/iPSA比率 (≥0.02) 与较短的OS显著相关 (HR 1.91,P < 0.0001),在PSM后得到证实 (HR 1.63,P = 0.0303).
高的BSI/iPSA比率独立预测了更糟糕的OS (HR2.03,P = 0.0046) 并与更低的仅PSA进展复发的可能性有关 (P = 0.0122).

结论:

根据BSI/iPSA比率所示,PSA水平和骨转移体积之间的不一致表明非PSA产生瘤.
这种不一致与转移性PCa的死亡风险增加有关.
BSI/iPSA比率可以帮助为转移性前列腺癌患者个性化治疗策略.

关键词:

受体受体是受体的受体.骨扫描指数指数骨扫描指数转移性荷尔蒙敏感前列腺癌前列腺癌是前列腺癌.前列腺特异抗原的前列腺特异抗原.

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